BETA
Your AI-Trained Oncology Knowledge Connection!
Chemoradiation Shows Long-Term Clinical Benefit in High-Risk Gastric Cancer
The incidence of grade 3 to 4 acute toxicities was similar in patients with high-risk gastric cancer treated with chemoradiation or chemotherapy.
Chemotherapy Confers No Survival Benefit in Older Breast Cancer Population
Adjuvant chemotherapy with hormonotherapy in women at least 70 years of age with GGI-high risk HER2-negative breast cancer led to more AEs vs hormonotherapy alone.
Frontline Immunotherapy May Offer Best Chance to Cure Kidney Cancer
Clinical trials still have a role in improving outcomes with immunotherapy among those with kidney cancer.
Navigating the Mental and Emotional Landscape of Cancer
Boris M. Kiselev, MD, discusses the role of psycho-oncology in comprehensive cancer care, addressing barriers and offering a vision for the field’s future.
Dendritic Cell Vaccine Shows Preliminary Activity in Advanced HCC
The addition of dendritic cells to TACE in patients with intermediate-stage HCC did not significantly increase the incidence or severity of AEs.
Staying Current: Your Guide to August 2025 Oncology Research
An oncologist’s passion for breast surgery, novel cancer vaccines in gastrointestinal cancers, and emerging actionable biomarkers for lung cancer were all covered in August.
Sonrotoclax Meets Primary ORR End Point in Mantle Cell Lymphoma
The safety profile of sonrotoclax was generally well-tolerated, and emergent toxicities were manageable in patients with mantle cell lymphoma.
FDA OKs Leuprolide Mesylate 3-Month Formulation in Advanced Prostate Cancer
Results from a phase 3 trial led to the approval of leuprolide mesylate as a 3-month formulation for patients with advanced prostate cancer.
FDA Accepts New Drug Application for Gedatolisib in PIK3CA Wild-Type Breast Cancer
The rolling submission is supported by data from the PIK3CA wild-type cohort of the phase 3 VIKTORIA-1 trial evaluating gedatolisib in advanced breast cancer.
FDA Grants 2 Fast Track Designations to TT125-802 in EGFR/KRAS G12C NSCLC
TT125-802 monotherapy shrank the tumors in 5 of 7 patients with drug-resistant NSCLC, and no thrombocytopenia was observed.
Episode 11: Testicular Cancer Treatment: Making an Informed Diagnosis
Beyond the BEP: A Deep Dive into Testicular Cancer Management
Discover key takeaways on tumor markers, the BEP vs. EP debate, and the role of surgery in stage II testicular cancer.
Abemaciclib/Endocrine Therapy Improves OS in HR+/HER2– Early Breast Cancer
Results from the monarchE study showed a statistically significant OS improvement with abemaciclib plus ET for patients with HR+/HER2– early breast cancer.
Overcoming Immunotherapy Resistance Mechanisms in Kidney Cancer
Current research initiatives in the kidney cancer field include exploring anti–PD-1, anti–LAG-3, and anti–CTLA-4 combination regimens.
Initiating Conversations on Mental Health in Oncology
Boris M. Kiselev, MD, provides practical advice for oncology clinicians on how to approach and initiate conversations about a patient’s mental and emotional well-being.
Though TAS-102 Achieved ctDNA Clearance, More Work is Needed
TAS-102 had a significant impact, achieving ctDNA clearance, in patients with colorectal cancer with ctDNA-defined MRD.
A Multifaceted Approach to Managing Cancer-Related Anxiety and Depression
Boris M. Kiselev, MD, explores evidence-based interventions for managing cancer-related anxiety and depression.
Pembrolizumab Combo Improves pCR Rate in Advanced Gastric/GEJ Cancer
Data from KEYNOTE-585 showed that adding pembrolizumab to chemotherapy did not negatively impact health-related quality of life vs placebo/chemotherapy.
Nogapendekin Alfa Inbakicept Combo Yields Disease Control in Glioblastoma
Results from a pilot phase 2 trial showed that all 5 patients who received treatment achieved a response or had stable disease.
Stenoparib Receives FDA Fast Track Designation in Advanced Ovarian Cancer
The novel treatment was evaluated in a phase 2 trial and saw a clinical benefit in patients with advanced ovarian cancer.
Pioneer of Supportive Care Highlights Additional Needs in The Space
Declan Walsh, MD, highlighted how the supportive and palliative care space has evolved since he first began working in the field.
Rina-S Earns FDA Breakthrough Therapy Designation in Endometrial Cancer
Data from the phase 1/2 RAINFOL-01 trial support the agency’s regulatory decision on rinatabart sesutecan in advanced endometrial cancer.
Psycho-Oncology is a Core Component of Comprehensive Cancer Care
Boris M. Kiselev, MD, discusses the essential role of psycho-oncology in addressing patient distress, improving treatment adherence, and supporting long-term survivorship.
DecisionDx-SCC Predicts Recurrence, Guides Imaging in Squamous Cell Carcinoma
Two studies were recently published that validated the use of the DecisionDx-SCC test as a tool for the treatment of cutaneous squamous cell carcinoma.
Haystack MRD Test Earns FDA Breakthrough Device Designation in Stage II CRC
Developers launched a clinical laboratory-developed test version of Haystack MRD in late 2024 and are further expanding access for oncologists.
AI Prognostic Tool Confirms Concordance Through Epigenomic Signatures in AML
Both experimental models significantly improved upon historical clinical risk trial groups for patients with acute myeloid leukemia.
Nutrition Research Is Needed to Enhance Outcomes in Oncology
Declan Walsh, MD, highlighted the need for nutrition research to enhance oncology care.
Rusfertide Earns FDA BTD for Erythrocytosis in Polycythemia Vera
Results from the phase 3 VERIFY trial of rusfertide for erythrocytosis in patients with polycythemia vera led to the FDA decision.
FDA Clears IND for IBI363 in Squamous Non–Small Cell Lung Cancer
Developers will now initiate the phase 3 MarsLight-11 trial of IBI363 among patients with immunotherapy-resistant squamous non–small cell lung cancer.
Integrating Supportive Care Into Everyday Practice
Being proactive and quickly identifying when a patient may need the supportive care team is the best way to integrate this field into whole-person care.
