May 7th 2024
All patients with a response to TAR-200 did not have progression to muscle-invasive bladder cancer or metastatic disease in the SunRISe-1 trial.
Systemic Therapy for Urothelial Carcinoma: Is a Renaissance Around the Corner?
June 15th 2016Since the development of first-line cisplatin-based combination chemotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin almost 3 decades ago, there have not been major advances in the treatment of this disease.
ASCO 2016: Nivolumab Effective in Metastatic Bladder Cancer, Regardless of Tumor PD-L1 Status
June 15th 2016Nivolumab is safe and effective in patients with metastatic bladder cancer refractory to prior lines of platinum-based chemotherapy, according to findings from the open-label, phase I/II CheckMate 032 trial.
Checkpoint Inhibitors and Urothelial Carcinoma: The Translational Paradigm
February 15th 2016The emergence of immune checkpoint inhibitors as effective cancer immunotherapy has effectively built a new “highway” connecting the promise of oncologic translational research to progress in treating advanced malignancies.
Efficacy of Low-Dose Gemcitabine, Paclitaxel, Sorafenib for Cisplatin-Resistant Urothelial Cancers
January 15th 2016Despite a high rate of hematologic toxicity, combined low-dose gemcitabine (Gemzar), paclitaxel, and sorafenib (Nexavar) showed promise as a well-tolerated salvage therapy in a small group of patients with cisplatin-resistant urothelial cancer.
Atezolizumab Shows Promise in Advanced Urothelial Carcinoma
January 11th 2016The anti-PD-L1 antibody atezolizumab showed significantly improved objective response rates compared to historic controls in a phase II study of patients with locally advanced or metastatic urothelial carcinoma previously treated with platinum-based therapy.
Lymphoepithelioma-Like Carcinoma of the Urinary Bladder
A 65-year-old woman presented to a local emergency department complaining of right flank pain that had worsened over the past 10 days. A CT scan of the abdomen and pelvis showed intravesical tumors of the urinary bladder.