May 7th 2024
Data from the phase 3 CRC-PREVENT trial support the sensitivity of ColoSense in the detection of colorectal cancer.
Medical Crossfire®: Critical Questions on Diagnosis, Sequencing, and Selection of Systemic and Radioligand Therapy Options for Patients with GEP-NETs
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Community Practice Connections™: 8th Annual School of Gastrointestinal Oncology®
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2024 International Symposium of Gastrointestinal Oncology (ISGIO)
October 11-12, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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The Next Wave in Biliary Tract Cancers: Leveraging Immunogenicity to Optimize Patient Outcomes in an Evolving Treatment Landscape
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Community Practice Connections™: 9th Annual School of Gastrointestinal Oncology®
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COMPASS: Genomic Profiling Could Guide Treatment in Advanced Pancreatic Cancer
February 2nd 2018In this interview we discuss preliminary results of the COMPASS trial, which used whole-genome sequencing and RNA sequencing to analyze the tumors of patients with advanced pancreatic ductal adenocarcinoma to identify possible first-line treatments.
No Benefit With Bevacizumab Maintenance Therapy for Metastatic CRC During Chemo-Free Intervals
January 25th 2018Adding bevacizumab maintenance therapy failed to improve outcomes compared with no treatment when administered during chemotherapy-free intervals to patients with metastatic colorectal cancer after induction chemotherapy.
HIPEC Increased Survival in Gastric Cancer With Peritoneal Metastasis
January 19th 2018Undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) resulted in improved overall survival compared with resection alone for patients with gastric cancer with peritoneal carcinomatosis, according to data presented at the 2018 Gastrointestinal Cancers Symposium.
Woman With Rare Cause of Rectal Bleeding
January 15th 2018A 56-year-old Caucasian woman presented to her primary care physician with a 3-month history of intermittent bright red rectal blood with defecation. At her initial visit, a digital rectal examination, anoscopy, and a pelvic examination with DNA testing for high-risk HPV were performed; all results were negative. She was referred for a colonoscopy, which revealed an abnormal area with a 3 × 4–cm mass in the rectum at a distance of 10 cm from the anal verge.
Smoking Status Correlates With Prognosis Following CRC Diagnosis
December 17th 2017A large meta-analysis found that current and former smoking status was associated with poorer colorectal cancer prognosis compared with never smoking, and that smoking cessation may improve survival over those who continue to smoke.
Pembrolizumab Active in Heavily Pretreated Esophageal Tumors
November 29th 2017Treatment with the anti–PD-1 antibody pembrolizumab resulted in durable antitumor activity with manageable side effects in patients with heavily pretreated, PD-L1–positive advanced esophageal carcinoma, according to phase IB results of the KEYNOTE-028 study.
Olaparib/Paclitaxel Failed to Improve Survival in Advanced Gastric Cancer
November 28th 2017The combination of olaparib plus paclitaxel failed to significantly improve overall survival compared with placebo plus paclitaxel in Asian patients with advanced gastric cancer, according to the phase III results of the GOLD study.
Aprepitant Warrants More Study for CINV in Patients on FOLFOX for CRC
November 16th 2017Aprepitant plus palonosetron and dexamethasone showed early promise for preventing chemotherapy-induced nausea and vomiting among patients with colorectal cancer who are undergoing FOLFOX chemotherapy, according to results of a small pilot study.
High HER3 Expression in Advanced CRC Related to Anti-EGFR Activity
October 30th 2017HER3 messenger RNA expression may serve as a biomarker for patients with RAS wild type colorectal cancer who will benefit from treatment with the anti-EGFR therapy panitumumab, according to the results of a new study.
Nonoperative Management of Rectal Cancer: A Modern Perspective
In this article, we provide a summary of nonoperative management of locally advanced rectal cancer in the modern era. Our focus is on technical details of tumor response and patient assessment after chemoradiotherapy, as well as a review of existing clinical data.
Adjuvant Chemo Improved Survival in Gastroesophageal Cancer
October 2nd 2017Treatment with adjuvant chemotherapy improved the overall survival of locally advanced gastroesophageal adenocarcinoma in patients treated with preoperative chemoradiotherapy and resection, according to the results of an analysis of the National Cancer Database.
MVA-5T4, Low-Dose Cyclophosphamide in mCRC Showed Survival Benefit
September 21st 2017A combination of modified vaccinia Ankara-5T4 (MVA-5T4) and low-dose cyclophosphamide, or either treatment given alone, demonstrated significant survival benefit in a small group of patients with metastatic colorectal cancer compared with no treatment.
Updated Results Show Continued Pembrolizumab Activity in Gastric Cancer
September 11th 2017Updated results from the KEYNOTE 059 phase II trial showed that pembrolizumab alone or in combination with chemotherapy has promising antitumor activity for patients with advanced gastric or gastroesophageal junction cancer.