Nina Shah, MD, discusses breakthroughs in the treatment of multiple myeloma throughout the preceding year.
Nina Shah, MD: One of the biggest breakthroughs that we've had for multiple myeloma is the first FDA-approved engineered T-cell therapy. It happened midway through the year in the spring, giving us the approval for the bb2121 product, also known as ide-cel [idecabtagene vicleucel; Abecma], for patients with relapsed or refractory multiple myeloma [after 4 or more prior lines of therapy]. That's probably the biggest breakthrough but we've also had some interesting other breakthroughs, which include approvals of certain forms of daratumumab (Darzalex), for example, the subcutaneous form, in conjunction with carfilzomib (Kyprolis) and dexamethasone for relapsed or refractory disease in [patients who received] 1 to 3 prior lines [of therapy]. Similarly, isatuximab (Sarclisa), carfilzomib, and dexamethasone has also been approved. We have a lot more options for our patients in the relapsed or refractory setting.
Relapsed/Refractory Multiple Myeloma Trial Updates From ASCO 2023
August 7th 2023Experts from Mayo Clinic and The University of Texas MD Anderson Cancer Center discuss results from multiple myeloma trials presented at the 2023 American Society of Clinical Oncology Annual Meeting and how they may apply to clinical practice.