News
Clinical Topics
Integrative Care
Global Bulletin
All News
Approval Alert
Media
2 Minute Drill
Around the Practice
Between the Lines
Clinical Consult
Expert Interviews
Face Off
Medical World News
Morning Rounds
OncView
Podcasts
Readout 360
Satellite Sessions
Sponsored Media
Training Academy
Year in Review
Conferences
Publications
All Journals
For Authors
Tumor Board
Events
Frontline Forum
CME/CE
Resources
Contemporary Concepts
Awareness Month
Interactive Tools
Nurse Practitioners/Physician's Assistants
Partners
Sponsored
Subscribe
Print Subscription
eNewsletter

logo
Spotlight
Around the Practice
Between the Lines
Contemporary Concepts
Journal
OncView
Podcasts
Readout 360
2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates
CancerNetwork® Inaugural Face-Off
Contemporary Concepts in Hematologic Oncology
Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice
Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer
Clinical
Acute Myeloid Leukemia
Brain Cancer
Breast Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Gynecologic Cancer
Hematology
Leukemia
Lung Cancer
Lymphoma
Pediatric Cancers
Skin Cancer
Clinical Topics
Integrative Care
Global Bulletin
All News
Approval Alert
2 Minute Drill
Around the Practice
Between the Lines
Clinical Consult
Expert Interviews
Face Off
Medical World News
Morning Rounds
OncView
Podcasts
Readout 360
Satellite Sessions
Sponsored Media
Training Academy
Year in Review
Conferences
All Journals
For Authors
Tumor Board
Frontline Forum
CME/CE
Contemporary Concepts
Awareness Month
Interactive Tools
Nurse Practitioners/Physician's Assistants
Partners
Sponsored
Print Subscription
eNewsletter
Advertisement
Breast Cancer
| Kidney Cancer
| Leukemia
| Lymphoma
| Multiple Myeloma
| Non-Small Cell Lung Cancer (NSCLC)
| Small Cell Lung Cancer (SCLC)
| Adverse Effects
| Biomarkers
| Bladder Cancer
| Brain Cancer
| Cervical Cancer
| Colorectal Cancer
| Endometrial Cancer
| Esophageal Cancer
| Gastrointestinal Cancer
| Genitourinary Cancers
| Gynecologic Cancers
| Head & Neck Cancer
| Hematology
| Hormone-related Cancers
| Immunotherapy
| Infection
| Liver Cancer
| Lung Cancer
| Mesothelioma
| Neuroendocrine Tumors
| Oncology
| Ovarian Cancer
| Ovarian Cancer Clincal Consult
| Pancreatic Cancer
| Pediatric Cancers
| Prostate Cancer
| Radiation Oncology
| Sarcoma
| Screening
| Skin Cancer & Melanoma
| Surgery
| Thoracic Malignancies
| Thyroid Cancer
View All >>
  • Adverse Effects
  • Biomarkers
  • Bladder Cancer
  • Brain Cancer
  • Breast Cancer
  • Cervical Cancer
  • Colorectal Cancer
  • Endometrial Cancer
  • Esophageal Cancer
  • Gastrointestinal Cancer
  • Genitourinary Cancers
  • Gynecologic Cancers
  • Head & Neck Cancer
  • Hematology
  • Hormone-related Cancers
  • Immunotherapy
  • Infection
  • Kidney Cancer
  • Leukemia
  • Liver Cancer
  • Lung Cancer
  • Lymphoma
  • Mesothelioma
  • Multiple Myeloma
  • Neuroendocrine Tumors
  • Non-Small Cell Lung Cancer (NSCLC)
  • Oncology
  • Ovarian Cancer
  • Ovarian Cancer Clincal Consult
  • Pancreatic Cancer
  • Pediatric Cancers
  • Prostate Cancer
  • Radiation Oncology
  • Sarcoma
  • Screening
  • Skin Cancer & Melanoma
  • Small Cell Lung Cancer (SCLC)
  • Surgery
  • Thoracic Malignancies
  • Thyroid Cancer

SPOTLIGHT -

Around the Practice
| Between the Lines
| Contemporary Concepts
| Journal
| OncView
| Podcasts
| Readout 360
| 2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates
| CancerNetwork® Inaugural Face-Off
| Contemporary Concepts in Hematologic Oncology
| Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice
| Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer

Elevation of Some Genomic, Inflammatory Markers Associated With Cancer-Related Fatigue

July 2, 2012
Dave Levitan
Article

High levels of certain immunogenomic and inflammatory markers are associated with cancer-related fatigue in some survivors, according to a review of existing literature.

High levels of certain immunogenomic and inflammatory markers are associated with cancer-related fatigue in some survivors, according to a review of existing literature. In many patients, though, adjustments for covariates yielded a confusing picture of relationships between these markers and fatigue.

“Fatigue is one of the most commonly reported symptoms in cancer with a prevalence rate of 59% to 100% depending on the clinical status of the disease,” wrote researchers led by Leorey Saligan, PhD, RN, of the National Institute of Nursing Research in Bethesda, Maryland, in Brain, Behavior, and Immunity. Research on connections between immune markers and cancer-related fatigue has been limited, which in turn could be limiting its management.

The authors reviewed 34 papers that examined connections between immunogenomic markers and fatigue. Specifically in longitudinal studies, they found that elevated fatigue symptoms particularly in women with early stages of breast cancer were associated with high levels of neutrophil/monocyte, interleukin-1ra (IL-1ra), and IL-6 during radiotherapy, and with high levels of CD4*, IL-1B, and IL-6 with stressing stimuli.

The cross-sectional studies, in general, failed to show consistent associations between the various markers and fatigue, especially when covariates such as body mass index and types of treatment were considered. Still, the authors noted that the longitudinal study review “provides empirical support for the association between high levels of cancer-related fatigue and elevated systemic inflammatory markers (CRP, neutrophils, monocytes, lymphocytes); increased signal of immune response (CD4*); high cytokine concentrations (IL-6, IL-1B) concentrations; and increased markers of cytokine activities (IL-1ra, sTNF-R1I).” Four cross-sectional studies did find significant associations between fatigue levels and signals of immune response.

The main result of such associations at this point is to identify gaps in our knowledge of fatigue and such markers and to plan further research accordingly. First of all, because only 29% of the total studies included in this review were longitudinal, there is a clear need to use such designs further in the future. Another methodological gap is the lack of a strong definition for cancer-related fatigue; 22 of the 34 studies did not conceptually define fatigue at all. Also, a number of different questionnaires were used to assess fatigue levels, only two of which were validated as sensitive to changes in cancer progression or treatment.

“Careful sample and study design selection, utilization of valid and reliable cancer-related fatigue measures that are sensitive to changes in fatigue over time, and inclusion of relevant covariates in statistical analyses are important considerations in designing future trials,” the authors wrote.

Study details

Ten of the 34 studies were longitudinal and 24 were cross-sectional. Eighteen studies enrolled only women, while only one enrolled only men; seven focused on terminal cases. There was one study of pediatric patients, and seven studies of breast cancer survivors that were all conducted by one research team.

Related Content

Emotional Health of Nurses Appears Continues to be Severely Impacted by the COVID-19 Pandemic, Survey Says

November 27th 2021

Influence of Aerobic Exercise on QOL During Prostate Cancer Treatment

May 8th 2017

Using the THRIVE Program to Teach Self-Care to Oncology Nurses

April 11th 2019

Pain Management in Cancer Patients at Risk of Opioid Abuse

May 5th 2017

How to Close Care Gaps in Vulnerable Populations

July 15th 2018

Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia

July 12th 2018

Emotional Health of Nurses Appears Continues to be Severely Impacted by the COVID-19 Pandemic, Survey Says

November 27th 2021

Influence of Aerobic Exercise on QOL During Prostate Cancer Treatment

May 8th 2017

Using the THRIVE Program to Teach Self-Care to Oncology Nurses

April 11th 2019

Pain Management in Cancer Patients at Risk of Opioid Abuse

May 5th 2017

How to Close Care Gaps in Vulnerable Populations

July 15th 2018

Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia

July 12th 2018

Emotional Health of Nurses Appears Continues to be Severely Impacted by the COVID-19 Pandemic, Survey Says

November 27th 2021

Influence of Aerobic Exercise on QOL During Prostate Cancer Treatment

May 8th 2017

Using the THRIVE Program to Teach Self-Care to Oncology Nurses

April 11th 2019

Pain Management in Cancer Patients at Risk of Opioid Abuse

May 5th 2017

How to Close Care Gaps in Vulnerable Populations

July 15th 2018

Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia

July 12th 2018
Related Content
Advertisement

One in 3 nurses do not feel emotionally health, a large number of whom have experienced trauma due to the COVID-19 pandemic and no longer wish to be in their job position.

Emotional Health of Nurses Appears Continues to be Severely Impacted by the COVID-19 Pandemic, Survey Says

November 27th 2021
Article

One in 3 nurses do not feel emotionally health, a large number of whom have experienced trauma due to the COVID-19 pandemic and no longer wish to be in their job position.


Influence of Aerobic Exercise on QOL During Prostate Cancer Treatment

Influence of Aerobic Exercise on QOL During Prostate Cancer Treatment

May 8th 2017
Podcast

In this interview we discuss a study that looked at the effect of an 8-week exercise intervention on treatment side effects for patients with prostate cancer.


Using the THRIVE Program to Teach Self-Care to Oncology Nurses

Using the THRIVE Program to Teach Self-Care to Oncology Nurses

April 11th 2019
Article

The THRIVE Program includes an 8-hour retreat designed to teach staff skills for combating compassion fatigue and for promoting resilience.


Pain Management in Cancer Patients at Risk of Opioid Abuse

Pain Management in Cancer Patients at Risk of Opioid Abuse

May 5th 2017
Podcast

In this interview we discuss pain management for cancer patients who are at high risk of opioid abuse.


How to Close Care Gaps in Vulnerable Populations

How to Close Care Gaps in Vulnerable Populations

July 15th 2018
Article

Oncology nurse leaders share insights into the care of vulnerable oncology populations-from ED triage to tailored telehealth sessions for homeless populations.


Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia

Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia

July 12th 2018
Article

A pilot protocol developed at Memorial Sloan Kettering Cancer Center resulted in exponential increases in both influenza and pneumococcal vaccinations in the outpatient setting.

About
Advertise
CureToday.com
OncLive.com
OncNursingNews.com
TargetedOnc.com
Contact
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Clarke Drive
Cranbury, NJ 08512

609-716-7777

© 2023 MJH Life Sciences

All rights reserved.