NCI Denies Media Report It Failed to Replicate Endostatin Findings

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 8 No 11
Volume 8
Issue 11

BETHESDA, Md-In a rare public confrontation with the media, the National Cancer Institute denied a report in the Wall Street Journal that its scientists had failed to replicate the work of Judah Folkman, PhD, showing that endostatin, an antiangiogenesis compound, dramatically shrinks tumors in mice.

BETHESDA, Md—In a rare public confrontation with the media, the National Cancer Institute denied a report in the Wall Street Journal that its scientists had failed to replicate the work of Judah Folkman, PhD, showing that endostatin, an antiangiogenesis compound, dramatically shrinks tumors in mice.

The NCI said that in February, two of its scientists conducted experiments in Dr. Folkman’s laboratory at Children’s Hospital, Boston that verified his previously published results. As a result of that work, the NCI said it decided to proceed with two phase I endostatin trials, one of which is now enrolling patients.

The Institute statement said that it had not conducted additional experiments with human or murine endostatin at any of its laboratories in Maryland, “meaning there have been no ‘failed’ laboratory studies with the material to be used in humans.” It noted that other experimenters had found that, in mice, human endostatin had caused “a marked inhibition of tumor growth, an indication that the human protein might also be effective in people".

Related Videos
Domenica Lorusso, MD, PhD, says that paying attention to the quality of chemoradiotherapy is imperative to feeling confident about the potential addition of pembrolizumab for locally advanced cervical cancer.
Exercise and healthy lifestyles can lower the risk of cancer or the symptoms of cancer treatment despite having genetic dispositions, said Neil M. Iyengar, MD.
Cell therapy and vaccine approaches are among the several potential options for targeting KRAS in patients with KRAS G12C–mutated non–small cell lung cancer, says Sandip P. Patel, MD.
Marwan G. Fakih, MD, and Atif Hussein, MD, MMM, FACP, experts on colorectal cancer
A panel of 4 experts on multiple myeloma seated at a long table
A panel of 4 experts on multiple myeloma seated at a long table
Experts on MM
Related Content