A 26-year-old man was diagnosed with the nodular sclerosing subtype of Hodgkin lymophoma, stage II-A. He was started on cyclic combination chemotherapy consisting of adriamycin, bleomycin, vinblastine, and dacarbazine ("ABVD" therapy). Although generally tolerating the treatment well, about 2 weeks after the second cycle of treatment, he noted and complained about slightly pruritic discoloration of his trunk. His left chest is depicted in the figure.
Which statement is true regarding this phenomenon?