Voreloxin Gets Orphan Drug Status for Acute Myeloid Leukemia

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OncologyONCOLOGY Vol 23 No 14
Volume 23
Issue 14

Sunesis Pharmaceuticals, Inc, announced that the US Food and Drug Administration has granted voreloxin orphan drug designation for the treatment of acute myeloid leukemia (AML). Sunesis is currently conducting two phase II clinical trials of voreloxin in AML: a single-agent study (REVEAL-1) in newly diagnosed elderly AML patients unlikely to benefit from standard induction chemotherapy and a study evaluating the drug in combination with cytarabine in relapsed/refractory AML.

Sunesis Pharmaceuticals, Inc, announced that the US Food and Drug Administration has granted voreloxin orphan drug designation for the treatment of acute myeloid leukemia (AML). Sunesis is currently conducting two phase II clinical trials of voreloxin in AML: a single-agent study (REVEAL-1) in newly diagnosed elderly AML patients unlikely to benefit from standard induction chemotherapy and a study evaluating the drug in combination with cytarabine in relapsed/refractory AML.

Voreloxin is a first-in-class anticancer quinolone derivative, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest, and apoptosis.

Articles in this issue
CYP2D6 Testing in Breast Cancer: Ready for Prime Time?
Tamoxifen, Endoxifen, and CYP2D6: The Rules for Evaluating a Predictive Factor
CYP2D6 Testing for Breast Cancer Patients: Is There More to the Story?
Adult T-cell Leukemia/ Lymphoma: Complexities in Diagnosis and Novel Treatment Strategies
Adjuvant Treatment After Orthotopic Liver Transplantation: Is It Really Necessary?
Recurrent Urothelial Carcinoma With Pulmonary Metastasis
Hepatocellular Carcinoma: The Search for Innovative Adjuvant Therapies
Getting a Handle on Posttransplant Recurrence of HCC
Survivin(g) Adult T-cell Leukemia/Lymphoma
Mediterranean Diet
Mediterranean Diet
Innovative Strategies Improve Outcomes and Reduce Complications Associated With Stem Cell Transplants
Advances in Optimizing Therapy and Quality of Life for People With Hard-to-Treat Blood Cancers
Advances in Genetics and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
Major Cancer Agencies Respond to USPSTF’s New Mammography Guidelines
CMS Releases 2010 Physician Fee Schedule

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