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2022 ASCO Genitourinary Cancers Symposium Urothelial Cancer Updates
CancerNetwork® Inaugural Face-Off
Contemporary Concepts in Hematologic Oncology
Insights from Experts at Mayo Clinic on Translating Evidence to Clinical Practice
Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer
Real-World Evidence in NSCLC Guides Clinical Decisions
Targeting NSCLC with Uncommon EGFR Mutations

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Alan K. Burnett, MD, FRCP | Authors

Getting to the Heart of Improving Outcomes for Patients With Acute Promyelocytic Leukemia

July 15, 2012

The management of patients with acute promyelocytic leukemia (APL) has been transformed over the course of the last two decades following the introduction of successful molecularly targeted therapies-all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)- which act in concert to induce degradation of the PMLRARα oncoprotein formed by the chromosomal translocation t(15;17)(q22;q21).