Distant Effects of Cancer on the Nervous System
November 01, 2002
Approximately 30 years passed between the first description of a paraneoplastic neurologic disorder and the demonstration of an immunologic pathogenesis for one of these syndromes. In the almost 4 decades since, the paraneoplastic neurologic disorders have been subjected to study far out of proportion to their clinical prevalence. These disorders stimulate clinical research because (1) paraneoplastic neurologic syndromes are frequently the presentation of a malignancy, (2) they may bode well for a more favorable tumor prognosis,[3,4] and most importantly, (3) they yield insight into the workings of malignancy and the pathogenesis of neurologic disorders, particularly neurologic degenerations.