Funda Meric-Bernstam, MD | Authors

End Results of Salvage Therapy After Failure of Breast-Conservation Surgery

March 01, 2004

Over the past 20 years, the combinationof breast-conservationsurgery and radiationtherapy has become the most commontreatment for the majority of patientswith invasive and in situ breastmalignancies. Extensive data fromboth randomized trials[1-3] and largeclinical databases have shown that thisapproach is equal to mastectomy interms of survival and provides excellentquality of life and patient acceptance.Nevertheless 10% to 15% ofpatients treated with breast-conservationsurgery and radiation will have alocal recurrence within the ipsilateralbreast (IBTR) within 10 years.[4-8]This paper will review the biology,clinical management, and outcomeof patients with ipsilateral breastrecurrence.