Melanoma’s Radioresistant Reputation Challenged
June 15, 2010
Conventional wisdom would have one believe that melanoma is a highly radioresistant tumor, perhaps even “radiation proof.” This reputation developed as a result of a combination of factors. First, early in vitro studies of melanoma radio-biology suggested that melanoma cells displayed enhanced postradiation survival vs comparison cells. Second, clinical use of radiation therapy for melanoma did not seem to work very well. This combination, a clinical observation supported by laboratory work, seems to have led radiation therapy to be avoided for melanoma treatment.