Lisa M. DeAngelis, MD | Authors

Chemotherapy-Induced Peripheral Neuropathy

March 15, 2016

Chemotherapy-induced peripheral neuropathy (CIPN) is a common treatment-related side effect of several widely used drugs. Agents known to cause CIPN include platinum analogs, antitubulins, proteasome inhibitors, immunomodulatory agents, and some of the newer biologics.

Cancer Management Chapter 23: Primary and metastatic brain tumors

March 11, 2010

Intracranial neoplasms can arise from any of the structures or cell types present in the cranial vault, including the brain, meninges, pituitary gland, skull, and even residual embryonic tissue. The overall annual incidence of primary brain tumors in the United States is 14 cases per 100,000 population.

Commentary (DeAngelis): Carcinomatous Meningitis: It Does Not Have to Be a Death Sentence

February 01, 2002

Leptomeningeal metastases are a growing problem, particularly among patients whose solid tumors have been controlled with increasingly effective systemic therapies. The central nervous system (CNS) can represent a sanctuary where disease can persist even if it is eradicated or controlled systemically. This is due to the blood-brain barrier that prevents most water-soluble chemotherapeutic agents from reaching tumor cells sequestered in the CNS.

Update on the Management of Primary CNS Lymphoma

February 01, 2000

Primary central nervous system (CNS) lymphoma is a non-Hodgkin’s lymphoma restricted to the nervous system. The incidence of this lymphoma is rising in the immunocompetent population but may be decreasing in patients

Biology and Treatment of Malignant Glioma

February 01, 1998

A large number of oncogenes have been identified as aberrant in gliomas, but only the erbB oncogene (gene encoding the epidermal growth factor receptor [EGFR]) is amplified in an appreciable number. The loss or

Current Management of Primary Central Nervous System Lymphoma

January 01, 1995

Primary CNS lymphoma is rising in incidence in both the AIDS and non-AIDS populations. It is a non-Hodgkin's lymphoma that usually presents as a brain tumor, but the leptomeninges, eyes, and spinal cord also are