Mark Hill, MD | Authors

UFT/Leucovorin Plus Irinotecan in Advanced or Metastatic Colorectal Cancer

October 01, 2000

UFT (with leucovorin) and irinotecan both have single-agent activity in colorectal cancer, with non–cross-resistant mechanisms of action. Combining these drugs would be anticipated to increase response rates while maintaining the advantages of a regimen based on an orally administered fluoropyrimidine.