Mark A. Weiss, MD

Articles

Chronic lymphocytic leukemia (CLL) is a clonal malignancy that results from expansion of the mature lymphocyte compartment. This expansion is a consequence of prolonged cell survival, despite a varied cell.

Chronic Lymphocytic Leukemia and Hairy-Cell Leukemia

Chronic lymphocytic leukemia (CLL) is a clonal malignancy that results from expansion of the mature lymphocyte compartment. This expansion is a consequence of prolonged cell survival, despite a varied cell. The affected lymphocytes are of B-cell lineage in 95% of cases, and the remaining cases involve T lymphocytes, representing a distinct disorder.

Cancer Management Chapter 31: Chronic lymphocytic leukemia

Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a clonal malignancy that results from expansion of the mature lymphocyte compartment. This expansion is a ­consequence of prolonged cell survival, despite a varied cell turnover. The affected lymphocytes are of B-cell lineage in 95% of cases, and the remaining cases involve T lymphocytes, representing a distinct disorder. CLL is the most common leukemia in adults in Western countries, accounting for approximately 25%-30% of all leuke­mias. The proportion of cases diag­nosed with the early stages of the disease (Rai stage 0) has risen from 10% to 50%, probably because of earlier diagnosis (routine automated blood counts).  

Author | Mark A. Weiss, MD

Articles

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