Author | Véronique Diéras, MD

Articles

Review of Docetaxel/Doxorubicin Combination in Metastatic Breast Cancer

August 01, 1997

ByVéronique Diéras, MD

Docetaxel (Taxotere) and doxorubicin (Adriamycin) have each demonstrated significant activity in metastatic breast cancer. Thus, the combination of docetaxel and doxorubicin has been evaluated in phase I trials to

Docetaxel in Combination With Doxorubicin: A Phase I Dose-Finding Study

June 01, 1997

ByVéronique Diéras, MD

This phase I dose-finding study examined the effects of the combination of doxorubicin and docetaxel (Taxotere) in 42 women with metastatic breast cancer. The combination was studied at six different dosing levels. The maximum tolerated doses were defined as doxorubicin, 50 mg/m², and docetaxel, 85 mg/m², with sepsis as the dose-limiting toxicity.