Brian Slomovitz, MD, Reviews Adjuvant Pembrolizumab and Chemo +/– Radiotherapy in Endometrial Cancer
During The Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer, CancerNetwork® spoke with Brian Slomovitz, MD, leader of endometrial trial for the Gynecologic Oncology Group (GOG) Foundation, and a gynecologic oncologist at Mount Sinai Medical Center in Miami Beach, Florida, about the phase 3 ENGOT-en11/GOG-3053/KEYNOTE-B21 trial in progress (NCT04634877) that is in progress with schema presented at the conference. This trial isHe and his co-investigators are examining observing the use of pembrolizumab (Keytruda) or vs placebo with plus adjuvant chemotherapy, with or without radiotherapy for patients who havewith newly diagnosed, high-risk endometrial cancer.
I’m fortunate enough at this meeting to present a trial in progress in the adjuvant setting in women with high-risk endometrial cancer [who are receiving] chemotherapy, plus or minus pembrolizumab in the treatment of this disease. One of the things that’s nice about this trial is that we’re allowing radiation therapy as an option based on clinician discretion. Now, adjuvant trials for endometrial cancer have been very difficult to get up and running. This study is looking to enroll 990 patients into a huge global trial sponsored by Merck and being run through ENGOT [European Network of Gynecological Oncological Trial Groups] and the GOG.
The purpose of this trial is to see if we can better the outcomes in women with high-risk endometrial cancer. Now at this point, we know that immunotherapy works in women with recurrent disease; if , whether they have microsatellite instability, immunotherapy in the single-agent setting would be indicated. Now if women are microsatellite stable, or what we call proficient in MMR, mismatch repair, then those women will get the combination of pembrolizumab and lenvatinib [Lenvima]. The purpose of this trial is to see if we can go back to 2 levels, not for first line but in the adjuvant setting, to see if immunotherapy works.
Slomovitz B, Mirza MR, Lortholary A, et al. ENGOT-en11/GOG-3053/KEYNOTE-B21: a phase 3 study of pembrolizumab or placebo in combination with adjuvant chemotherapy with or without radiotherapy in patients with newly diagnosed high-risk endometrial cancer. Presented at: Society of Gynecologic Oncology 2022 Annual Meeting on Women’s Cancer. March 18-21, 2022. Phoenix, AZ. Poster 570.