Duration of tamoxifen use influences cancer risk in opposite breast

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 18 No 10
Volume 18
Issue 10

Long-term tamoxifen use among breast cancer survivors is associated with a more than fourfold increased risk of ER-negative cancer in the contralateral breast, according to the investigators at Seattle’s Fred Hutchinson Cancer Research Center.

Long-term tamoxifen use among breast cancer survivors is associated with a more than fourfold increased risk of ER-negative cancer in the contralateral breast, according to the investigators at Seattle's Fred Hutchinson Cancer Research Center.

Comparing breast cancer patients who received tamoxifen to those who did not in 1,103 subjects, researchers found that while the drug was associated with a 60% reduction in ER-positive secondary breast cancer, the risk of ER-negative secondary went up by 440%.

"This is of concern, given the poorer prognosis of ER-negative tumors, which are also more difficult to treat," said lead author Christopher Li, MD, PhD. "Still, the benefits of this therapy are well established and doctors should continue to recommend hormonal therapy for breast cancer patients who can benefit from it" (Cancer Res online, August 24, 2009). These findings confirm preliminary research by Dr. Li's group, which was the first to suggest a link between long-term tamoxifen use and an increased risk of ER-negative second cancers (J Natl Cancer Inst 93:1008-1013, 2001).

The current study is the first to determine if tamoxifen use among survivors influences their risk of a second cancer, Dr. Li said.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
Breast oncologist Jade E. Jones, MD, says she tries to send patients with BRCA-mutant HR-positive TNBC to clinical trials that use PARP inhibitors.
Following progression on a CDK4/6 inhibitor, ascertaining the endocrine sensitivity of HR-positive/HER2-negative disease may inform sequential treatment.
T-DXd improved progression-free survival over standard chemotherapy among patients with HR-positive/triple-negative breast cancer in DESTINY-Breast04.
The use of chemotherapy trended towards improved recurrence-free intervals in older patients with high-risk tumors as determined via the MammaPrint assay.
Use of a pharmacist-directed resource appears to improve provider confidence and adverse effect monitoring for patients undergoing infusion therapy.
Reshma L. Mahtani, DO, describes how updates from the DESTINY-Breast09, ASCENT-04, and VERITAC-2 trials may shift practices in the breast cancer field.
Multidisciplinary care can help ensure that treatment planning does not deviate from established guidelines for inflammatory breast cancer management.
Related Content