A 72-year-old woman presents with a lesion on the left posterior thigh.

Paget’s disease has ubiquitous distribution and can occur in different anatomic areas. Caucasian women appear to be affected more than men with an average age of 60-65 years. Often, an associated adnexal carcinoma may be present. The histogenesis of this process is still unknown. Several possibilities are commonly considered in the differential diagnosis including squamous cell carcinoma and melanoma. Therefore, careful histological and immunohistochemical evaluations are important in the assessment of Paget’s disease.

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A 72-year-old woman presents with a lesion on the left posterior thigh. What is your diagnosis?

Elderly Woman With a Thigh Lesion