Hodgkin's Disease Patients Sought for Trial of MoAb

BOSTON, Mass--Researchers at New England Deaconess Hospital areseeking Hodgkin's disease patients for a federally funded phaseIb/II trial of a humanized monoclonal antibody (MoAb) againstinterleukin-2 receptor (Tac).

The rationale for the study stems from the observation that allReed-Sternberg cells are Tac-positive. The monoclonal antibodyunder study is the humanized version of the murine anti-Tac antibodythat generated a 33% response rate (partial response plus completeresponse) in 19 patients with ATL (adult T-cell leukemia/lymphoma)at the National Cancer Institute (see figure).

The new molecule is 92% human in origin, resulting in increasedeffectiveness in cytotoxicity assays and reduced immunogenicityduring therapy (Queen et al: Proc Natl Acad Sci USA 86:10029,1989; Junghans et al: Cancer Research 50:1495, 1990).

Eligibility requirements for the protocol (92-0205-34) includemeasurable disease, failed first- and second-line treatments,and PS 0-2. Patients must be able to remain in Boston for thefirst study month of this outpatient trial. Treatment responseat 1 month is required to continue participation.

For more information, contact Richard P. Junghans, PhD, MD, atNew England Deaconess Hospital; telephone:

617-632-0943; fax: 617-632-0998.