Key Points in the Treatment of Locally Advanced
Inoperable Pancreatic Cancer
- Local tumor progression leads to mortality in 30% to 50% of patients with locally advanced pancreatic cancer.
- All standard therapies, including low-dose palliative stereotactic body radiotherapy (SBRT), offer little hope of long-term survival.
- Hypofractionation with an SBRT technique in 15–28 fractions allows an expansion of the therapeutic index. Biocorrected doses of 77.2–97.9 Gy (63–70 Gy in 28 fractions or 60–67.5 Gy in 15 fractions) in selected patients appear to offer a hope of long-term survival similar to that of surgery.