Treatment of Posttransplant Lymphomas
September 15, 2010
Jacobson and LaCasce have provided a thorough review of post-transplant lymphoproliferative disorders (PTLDs), but the authors did not completely cover the field. While the article describes the development of lymphoid tumors related to Epstein-Barr virus (EBV) in patients who have received an organ transplant, it did not consider PTLDs developing after hematopoietic stem cell transplant, a condition also related to EBV but which is more aggressive. Not all PTLD cases are related to EBV, however, and as in patients with HIV (human immunodeficiency virus) infection or hereditary immune deficiency, other lymphoma subtypes may be observed, including T-cell lymphomas (anaplastic large cell lymphoma,[2,3] hepatosplenic lymphoma), indolent lymphomas; and also Hodgkin lymphoma,[6,7] multiple myeloma, or lymphoproliferative disorders associated with human herpes virus 8 infection.