April 1st 2005
The Groupe d’Etude des Lymphomes de l’Adulte (GELA) has conductedseveral phase II and III studies in patients with aggressive lymphoma,diffuse large B-cell lymphoma (DLBCL), and T-cell lymphomasduring the past 20 years, in France and Belgium. These studieshave demonstrated that the outcome of patients with DLBCL may beimproved and that the standard CHOP (cyclophosphamide, doxorubicinHCl, vincristine [Oncovin], prednisone) regimen is not sufficient tocure a large number of patients. The first improvement was the demonstrationof superiority of a dose-dense and dose-intense regimen, ACVBP(doxorubicin [Adriamycin], cyclophosphamide, vindesine, bleomycin,prednisone). The second improvement was made in young patients withpoor-risk lymphoma by intensifying their treatment with high-dosetherapy and autotransplant. The third and most significant improvementwas in the results associated with the combination of rituximab(Rituxan) and chemotherapy. Current studies look at decreasing thenumber of patients truly refractory to chemotherapy, decreasing relapserate with rituximab maintenance, and finding an appropriate regimenfor patients with T-cell lymphoma.