David B. Page, MD | Authors

CTLA-4 Antibodies: New Directions, New Combinations

November 11, 2014

This review will summarize the preclinical and clinical development of CTLA-4–blocking antibodies, discuss recent insights into the biology of CTLA-4 blockade, review the use of these antibodies in combination with established and novel therapeutic modalities, and comment on ongoing questions regarding their administration.