Jiro Shibata, MSC | Authors

UFT and Its Metabolites Inhibit Cancer-Induced Angiogenesis via a VEGF - Related Pathway

October 01, 2000

Treatment with UFT for spontaneous lung metastasis of murine renal carcinoma (RENCA) after resection of the primary tumor has resulted in significant prolongation of the life span of tumor-bearing animals. UFT inhibited the growth of metastatic nodules in the lung, apparently via decreased density of microvessels in the metastatic foci. Subsequent experiments used dorsal air sac assay to directly trace newly forming microvessels.