Kathlyn Stone | Authors

BRAF inhibition may enhance immunotherapy in melanoma

July 13, 2010

A preclinical study provides the rationale for combining BRAF-targeted therapy with immunotherapy agents in patients with BRAF mutations. These mutations activate the MAPK signaling pathway, which leads to increased oncogenic potential. The researchers showed that in BRAF-mutant melanoma cell lines, a selective BRAF inhibitor (PLX4720) blocked the MAPK pathway and increased tumor antigen expression without affecting T-cell function.

State breast cancer screening programs struggle financially

May 17, 2010

There’s no shortage of controversy when it comes to mammography-based breast cancer screening.

Reimbursement for new RT lags behind implementation

September 01, 2008

Advanced applications, such as image-guided radiation therapy (IGRT) and stereotactic body radiotherapy (SBRT), are being rapidly deployed in radiation oncology.