Russell Devore, MD | Authors

Paclitaxel, Carboplatin, and Radiation Therapy for Non-Small-Cell Lung Cancer

January 02, 1998

Preclinically, the taxanes appear to potentiate radiation more effectively than do the platinum compounds. In our phase I trial (LUN-17) in patients with advanced non-small-cell lung cancer, we defined the maximum tolerated

Paclitaxel and Vinorelbine in Non-Small-Cell Lung Cancer

October 02, 1997

Paclitaxel (Taxol) and vinorelbine (Navelbine) are both microtubule toxins but with opposite mechanisms of action. Paclitaxel promotes the assembly of microtubules, whereas vinorelbine prevents microtuble assembly.