Walter Alexander | Authors

METROPOLITAN HOSPITAL CENTER

1901 1ST AVE

Articles

Ofatumumab generates high response rates in refractory CLL

December 10, 2010

Ofatumumab (Arzerra) demonstrated clinical benefit was superior to historic outcomes with salvage therapies in this setting, according to lead investigator William G. Wierda, MD, PhD. After about 26 months of median follow-up, progression-free survival and overall survival improved in fludarabine-refractory chronic lymphocytic leukemia and in fludarabine-refractory CLL with bulky lymph nodes.

Deeper Molecular Responses Seen with Dasatinib in New Chronic Myeloid Leukemia

December 07, 2010

The median reductions in Bcr-Abl transcripts at one year were greater with dasatinib (Sprycel) than with imatinib (Gleevec), according to the results of an intergroup phase II trial. A better molecular response should eventually correlate with better outcomes, making dasatinib a serious contender for upfront therapy in CML.

Letrozole appears less detrimental than tamoxifen to cognitive function in breast ca

July 28, 2009

Research by the International Breast Cancer Study Group furthers knowledge on how anti-estrogen agents affect cognitive function and memory.

Sequential triplet therapy proves safe, predictable for multiple myeloma

December 08, 2008

Bortezomib-based combination induction therapy paired with thalidomide offers a promising addition to the treatment armamentarium for multiple myeloma, according to results of a phase II study.

Rasburicase reduces tumor lysis risk in hematologic malignancies

December 08, 2008

Rasburicase (RAS) is superior to allopurinol in adult patients with hematological malignancies whose treatment puts them at high risk for developing tumor lysis syndrome or who have hyperuricemia at baseline, according to a study out of Houston’s M.D. Anderson Cancer Center.

Strong nilotinib responses in imatinib-failed CP-CML

May 01, 2008

This update, of patients with 11 months or greater follow-up, showed a complete hematologic response in 77% of patients receiving nilotinib, with a major cytogenetic response in 57.

Rapid responses to nilotinib in newly diagnosed early Ph+ CML

May 01, 2008

ORLANDO-In newly diagnosed, early chronic phase, Ph+ chronic myelogenous leukemia, nilotinib (Tasigna) quickly induced complete cytogenetic responses and was well tolerated, Jorge Cortes, MD, of M.D. Anderson Cancer Center, said at ASH 2007 (abstract 29).

Pooled results confirm Len/Dex benefits in myeloma

March 01, 2008

Multiple myeloma patients receiving lenalidomide (Revlimid) plus dexamethasone had improved responses, longer time to progression, and improved overall survival than those receiving dexamethasone alone in pooled phase III clinical trial results. Donna Weber, MD, of M.D. Anderson Cancer Center, presented the findings at ASH 2007 (abstract 412).

IRIS 6-year data confirm imatinib as standard CML Rx

February 01, 2008

Six-year results of the IRIS trial confirm imatinib (Gleevec) as the standard first-line therapy for chronic myelogenous leukemia