8 Concordance of Tumor Response with Eribulin Use in Real-World Clinical Practice

Publication
Article
Miami Breast Cancer Conference® Abstracts Supplement38th Annual Miami Breast Cancer Conference® - Abstracts
Volume 35
Issue suppl 1
Pages: 14

Bruce A. Feinberg, DO1; Jingchuan Zhang, PhD2; Jonathan K. Kish, PhD, MPH1; Shrividya Iyer, PhD2; Sarah S. Mougalian, MD3

1Cardinal Health Specialty Solutions, Dublin, OH

2Eisai Inc., Woodcliff Lake, NJ

3Yale Cancer Center, Yale School of Medicine, New Haven, CT

Background

Although clinical trials in advanced cancer routinely adopt criteria like the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, response assessment in clinical practice may be subjective; criteria utilized to assess response are not always reported in patient records. We report on the concordance of treatment response with eribulin use in clinical practice, as evaluated through 2 assessment approaches in patients with metastatic breast cancer (mBC).

Methods

Adult female patients with mBC, initiating eribulin between 2011 and 2017 consistent with the approved United States indication, underwent chart abstraction by medical oncologists invited to participate. The best response to eribulin (complete response [CR], partial response [PR], stable disease [SD], or progressive disease [PD]) was assessed via 2 methods: 1) provider-reported best response abstracted from the medical record; and 2) response retrospectively calculated per RECIST v1.1 using measurements of target lesions provided by the treating oncologist. The proportion of concordant/discordant responses was compared between the 2 methods.

Results

Data from 513 patients were provided by 46 medical oncologists from across the United States in practices of various sizes (from small community to hospital owned); provider-reported best responses were available for all patients, and lesion measurements were obtained for
499 (97%). Best response rates reported by providers were 8% CR, 46% PR, 17% SD, and 29% PD. Best response rates were 2% CR, 44% PR, 29% SD, and 22% PD by calculation based on lesion measurements and RECIST v1.1 criteria. Concordance of best response classification was 77% overall. Discordant cases observed were mainly due to the classification of provider-reported CR and PR/PD as PR and SD, respectively, using lesion assessments (Table).

TABLE. Best Response in mBC Patients Treated With Eribulin

TABLE. Best Response in mBC Patients Treated With Eribulin

Conclusion

Concordance of 77% was observed between the
2 methods used to classify best response in eribulin-treated mBC. Response calculated per established criteria like RECIST using available lesion measurements in addition to provider-reported assessments in real-world studies of mBC could help to optimize the validity of outcomes assessment in clinical practice.

Articles in this issue

1 The Tolerance of CREATE-X Capecitabine Dosing in a United States TNBC Patient Population
1 The Tolerance of CREATE-X Capecitabine Dosing in a United States TNBC Patient Population
6 Survival Benefit of Eribulin, But Not Capecitabine, for Metastatic Breast Cancer Is Associated With Baseline Absolute Lymphocyte Count in Peripheral Blood
6 Survival Benefit of Eribulin, But Not Capecitabine, for Metastatic Breast Cancer Is Associated With Baseline Absolute Lymphocyte Count in Peripheral Blood
7 Evaluation of the 21-Gene Recurrence Score (RS) Assay Results Following Successful Intraoperative Radiation Therapy (IORT) Treatment of Patients With Early-Stage Breast Cancer
7 Evaluation of the 21-Gene Recurrence Score (RS) Assay Results Following Successful Intraoperative Radiation Therapy (IORT) Treatment of Patients With Early-Stage Breast Cancer
8 Concordance of Tumor Response with Eribulin Use in Real-World Clinical Practice
8 Concordance of Tumor Response with Eribulin Use in Real-World Clinical Practice
13 Real-world Treatment Patterns and Tumor Response of Palbociclib Plus an Aromatase Inhibitor for Metastatic Breast Cancer: Flatiron Database Analysis
13 Real-world Treatment Patterns and Tumor Response of Palbociclib Plus an Aromatase Inhibitor for Metastatic Breast Cancer: Flatiron Database Analysis
14 Real-World (RW) Treatment Patterns and Clinical Effectiveness of Palbociclib (PAL) Plus an Aromatase Inhibitor (AI) as First-Line Therapy in Advanced/ Metastatic Breast Cancer (A/MBC): Analysis From Syapse Learning Health Network
14 Real-World (RW) Treatment Patterns and Clinical Effectiveness of Palbociclib (PAL) Plus an Aromatase Inhibitor (AI) as First-Line Therapy in Advanced/ Metastatic Breast Cancer (A/MBC): Analysis From Syapse Learning Health Network
25 A Retrospective Cohort Study of Demographic, Clinical, and Treatment Characteristics of Patients With Metastatic Breast Cancer Who Have Received PARP Inhibitors
25 A Retrospective Cohort Study of Demographic, Clinical, and Treatment Characteristics of Patients With Metastatic Breast Cancer Who Have Received PARP Inhibitors
28 Primary Outcome Analysis of Invasive Disease-Free Survival for monarchE: Abemaciclib Plus Adjuvant Endocrine Therapy for High-Risk Early Breast Cancer
28 Primary Outcome Analysis of Invasive Disease-Free Survival for monarchE: Abemaciclib Plus Adjuvant Endocrine Therapy for High-Risk Early Breast Cancer
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30 Open-Label, Phase 1 Study to Evaluate Duration of Severe Neutropenia After Same-Day Dosing of Eflapegrastim in Patients With Early- Stage Breast Cancer (ESBC) Receiving Docetaxel and Cyclophosphamide
35 Decreased Epithelial Mesenchymal Transition Process After AGTR-1 Gene Edition By Crispr/Cas9, Losartan, and PARP Inhibitor Treatment In Breast Cancer Cell Line
35 Decreased Epithelial Mesenchymal Transition Process After AGTR-1 Gene Edition By Crispr/Cas9, Losartan, and PARP Inhibitor Treatment In Breast Cancer Cell Line
37 Treatment Outcomes Using Neoadjuvant Chemotherapy for HER2-Positive Breast Cancer in African American and Hispanic Women
37 Treatment Outcomes Using Neoadjuvant Chemotherapy for HER2-Positive Breast Cancer in African American and Hispanic Women
42 The United States Retrospective Claims Database Analysis of Demographic, Clinical, and Treatment Characteristics of Metastatic Breast Cancer Patients receiving Olaparib
42 The United States Retrospective Claims Database Analysis of Demographic, Clinical, and Treatment Characteristics of Metastatic Breast Cancer Patients receiving Olaparib
43 Lobular Cancer Responsiveness to Chemotherapy Is Equivalent to That of Ductal Cancer With Similar Genomic Profiles: An NCDB Analysis
43 Lobular Cancer Responsiveness to Chemotherapy Is Equivalent to That of Ductal Cancer With Similar Genomic Profiles: An NCDB Analysis
44 Drivers of Oncologist Treatment Selection in HR+/HER2- Metastatic Breast Cancer
44 Drivers of Oncologist Treatment Selection in HR+/HER2- Metastatic Breast Cancer
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