|Articles|August 1, 2007

Oncology NEWS International

  • Oncology NEWS International Vol 16 No 8
  • Volume 16
  • Issue 8

Avalon initiates phase II trial of AVN944 in pancreatic cancer

Avalon initiates phase II trial of AVN944 in pancreatic cancer

GERMANTOWN, Maryland—Avalon Pharmaceuticals, Inc. has initiated a phase II clinical trial of AVN944 in combination with gemcitabine (Gemzar) in patients with newly diagnosed pancreatic cancer. After a dose-escalation phase, approximately 110 to 120 patients will be enrolled in an efficacy and safety phase. AVN944 is an oral small molecule agent that inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling.

Articles in this issue

almost 19 years ago

Avoiding copay shock

almost 19 years ago

Induction chemo increases survival in unresectable NSCLC

almost 19 years ago

Superselective chemo strategies for HCC

almost 19 years ago

'Value meal dosing' of lapatinib is proposed

almost 19 years ago

AMA approves CPT code for Axxent electronic brachytherapy

almost 19 years ago

Zevalin/R after CHOP-R doubles CRs in follicular NHL

almost 19 years ago

Active surveillance with delayed treatment appears to be a safe option for younger men with low-risk prostate cancer

almost 19 years ago

RT plus local paclitaxel gel promising in esophageal ca

almost 19 years ago

GeneSearch BLN Assay gets FDA approval for node assessment during surgery

almost 19 years ago

TH vs TCH in metastatic breast cancer: 'Take your pick'

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