Chemotherapeutic agents and their uses, dosages, and toxicities

April 21, 2009

Chemotherapeutic agents and their uses, dosages, and toxicities

The chemotherapeutic agents included in this Appendix are classified by mechanism of action and are organized as follows:

• alkylating agents;

• antimetabolites;

• natural products;

• targeted agents
– monoclonal antibodies
– molecularly targeted therapies

FDA-approved uses and dose-limiting effects are set in italic type for emphasis. For a complete discussion of these mechanisms of action, see chapter 3 on “Principles of oncologic pharmacotherapy.”

FIGURE: Alkylating Agents

FIGURE: Antimetabolites

FIGURE: Natural Products

FIGURE: Targeted therapies: Monoclonal antibodies

FIGURE: Molecularly targeted therapies