Daniel P. Petrylak, MD, Says Maintenance Immunotherapy Has Become Standard Practice in Bladder Cancer

Video

At the 15th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies, Daniel P. Petrylak, MD, spoke about how immunotherapy has influenced treatment for patients with bladder cancer.

CancerNetwork® spoke with Daniel P. Petrylak, MD, professor of medicine (medical oncology) and of urology and co-leader of Cancer Signaling Networks at Yale Cancer Center, about using maintenance immunotherapy as a standard of care for patients with bladder cancer. He spoke on the topic at the 15th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies, hosted by Physicians’ Education Resource®, LLC (PER®), for which he served as meeting co-chair.

Transcript:

Immunotherapy is now considered standard of care for patients who respond to frontline chemotherapy for metastatic urothelial carcinoma. By respond, I define that as stable, complete, or partial response to chemotherapy, which could be either cisplatin and gemcitabine, carboplatin and gemcitabine, or the MVAC regimen [which includes methotrexate, vinblastine sulfate, doxorubicin hydrochloride, and cisplatin]. There’s a significant improvement in survival in those patients who receive maintenance of avelumab [Bavencio] compared with those who receive just best standard of care in that setting. We view that as standard treatment for these patients.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
Despite CD19 CAR T-cell therapy exhibiting efficacy in patients with relapsed/refractory large B-cell lymphoma, less than half achieve long-term remission.
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
Considering which non–muscle-invasive bladder cancer cases may be cured by surgery alone may help mitigate overtreatment in this patient group.
Event-free survival benefit was observed among BCG-naïve patients with carcinoma in situ undergoing treatment with sasanlimab plus BCG.
Related Content