Global BulletinAll NewsFDA Approval AlertWomen in Oncology
Expert InterviewsAround the PracticeBetween the LinesFace OffFrom All AnglesMeeting of the MindsOncViewPodcastsTraining AcademyTreatment Algorithms with the Oncology BrothersVideos
Conferences
All JournalsEditorial BoardFor AuthorsYear in Review
Frontline ForumSatellite Sessions
CME/CE
Awareness MonthInteractive ToolsNurse Practitioners/Physician's AssistantsPartnersSponsoredSponsored Media
Career CenterSubscribe
Adverse Effects
Brain Cancer
Breast CancerBreast CancerBreast Cancer
Gastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal Cancer
Genitourinary CancersGenitourinary CancersGenitourinary CancersGenitourinary Cancers
Gynecologic CancersGynecologic CancersGynecologic CancersGynecologic Cancers
Head & Neck Cancer
Hematologic OncologyHematologic OncologyHematologic OncologyHematologic Oncology
InfectionInfection
Leukemia
Lung CancerLung CancerLung Cancer
Lymphoma
Neuroendocrine Tumors
Oncology
Pediatric Cancers
Radiation Oncology
Sarcoma
Screening
Skin Cancer & Melanoma
Surgery
Thyroid Cancer
Spotlight -
  • Radiation Oncology
  • Surgery
Adverse Effects
Brain Cancer
Breast CancerBreast CancerBreast Cancer
Gastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal CancerGastrointestinal Cancer
Genitourinary CancersGenitourinary CancersGenitourinary CancersGenitourinary Cancers
Gynecologic CancersGynecologic CancersGynecologic CancersGynecologic Cancers
Head & Neck Cancer
Hematologic OncologyHematologic OncologyHematologic OncologyHematologic Oncology
InfectionInfection
Leukemia
Lung CancerLung CancerLung Cancer
Lymphoma
Neuroendocrine Tumors
Oncology
Pediatric Cancers
Radiation Oncology
Sarcoma
Screening
Skin Cancer & Melanoma
Surgery
Thyroid Cancer
    • Conferences
    • CME/CE
    • Career Center
    • Subscribe

Your AI-Trained Oncology Knowledge Connection!

scout
Advertisement

Early Intervention Important for Sunitinib-Related Hypertension in RCC

November 26, 2016
By Leah Lawrence
Article

Patients with metastatic renal cell carcinoma treated with sunitinib often experience treatment-related hypertension and require rigorous blood pressure control.

Patients with metastatic renal cell carcinoma (RCC) treated with sunitinib often experience treatment-related hypertension (tHTN). A retrospective study published recently in Clinical Genitourinary Cancer showed that these patients require rigorous blood pressure control and that the use of calcium channel blockers was best for controlling hypertension compared with other antihypertensive drugs.  

“Early intervention for tHTN might be important when blood pressure increases above the threshold of 140/90 mm Hg,” wrote researcher Philipp Ivanyi, MD, of Hanover Medical School, Germany, and colleagues. “In the absence of confounding factors (such as congestive heart failure), nondihydropyridine calcium channel blocker is the best way to quickly and reliably control tHTN.”

Sunitinib works by inhibiting the vascular endothelial growth factor (VEGF). In tumor cells, this signal inhibits tumor vasculature; however, in healthy cells it is associated with tHTN. Previous studies have shown a risk for hypertension among patients treated with VEGF receptor inhibitors and sunitinib, but because cardiovascular risk factors are common in patients with metastatic RCC, Ivanyi and colleagues wanted to explore the occurrence of this adverse event further.

They conducted a retrospective study of 72 patients with metastatic RCC treated with sunitinib from June 2004 to December 2011. They examined their medical records for risk factors for tHTN and antihypertensive treatments.

A little more than 70% of patients in the study developed tHTN after a median of 28 days on sunitinib. The mean blood pressure increased from 130/75 mm Hg on day 1 to 140/80 mm Hg on day 28. Only patients with tHTN had significant increases in blood pressure while on sunitinib.

The researchers found that a standard dose of sunitinib, age older than 50 years, and prehypertension were all independent risk factors for developing tHTN.

Antihypertensive therapies significantly reduced blood pressure among patients with tHTN. Among the patients diagnosed with tHTN, 70.8% received some kind of antihypertensive treatment and 72.5% received at last one modification of the antihypertension therapy at a median of 3 days after detection of tHTN. Calcium channel blockers were significantly better at controlling tHTN compared with other drugs (P = .045).

The researchers said that the results of this study should be interpreted with caution.

“In particular, the predominantly administered calcium channel blocker might cause an overestimation of its true efficacy in our statistical model,” they wrote. In addition, within the study period there were patients lost to follow-up or incomplete medical records.

Routine and permanent blood pressure monitoring should be considered in patients at high risk of tHTN, the researchers wrote, including patients older than 50 years of age, with pre-hypertension, or with a once daily sunitinib starting dose of 50 mg. “If control of tHTN is inadequate, an early combination of agents with different mechanisms of action may provide better control of tHTN.”

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Subscribe Now!
Recent Videos
Considering which non–muscle-invasive bladder cancer cases may be cured by surgery alone may help mitigate overtreatment in this patient group.
Event-free survival benefit was observed among BCG-naïve patients with carcinoma in situ undergoing treatment with sasanlimab plus BCG.
Various methods of communication ensure that members from radiation oncology, pathology, and other departments are on the same page regarding treatment.
Comprehensive prehabilitation may help prepare patients for bladder-preserving surgery, helping to optimize quality of life outcomes.
Ongoing research suggests environmental exposures and the role of microbiomes may influence bladder cancer development and response to treatment.
Related Content

First-Line Radiotherapy Combo May Show Benefit in Oligoprogressive HCC

First-Line Radiotherapy Combo May Show Benefit in Oligoprogressive HCC

Tim Cortese
June 19th 2025
Article

First-line systemic therapy plus radiation therapy improved PFS vs second-line systemic therapy with or without radiation in hepatocellular carcinoma.


Unveiling Advances in GU Cancers: Insights from Oncology Decoded

Unveiling Advances in GU Cancers: Insights from Oncology Decoded

Manojkumar Bupathi, MD, MS;Benjamin Garmezy, MD;John Burke, MD;Dhaval R. Shah, MBBS
July 3rd 2025
Podcast

Dive into the latest in genitourinary oncology with "Oncology Decoded," featuring discussions on KEYNOTE-564 with RCC.


There appeared to be no extra benefit with the addition of nivolumab to tivozanib among patients included in the phase 3 TiNivo-2 trial.

Tivozanib Shows Efficacy in Pretreated Metastatic RCC

Kyle Doherty
June 11th 2025
Article

There appeared to be no extra benefit with the addition of nivolumab to tivozanib among patients included in the phase 3 TiNivo-2 trial.


A Sneak Peek at 2025 ASCO From the GU Perspective

A Sneak Peek at 2025 ASCO From the GU Perspective

Manojkumar Bupathi, MD, MS;Benjamin Garmezy, MD
May 15th 2025
Podcast

Manojkumar Bupathi, MD, MS, and Benjamin Garmezy, MD, highlight exciting trials in the genitourinary cancer space expected to be presented at 2025 ASCO.


The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.

CAN-2409/EBRT Improves Disease-Free Survival in Localized Prostate Cancer

Roman Fabbricatore
June 3rd 2025
Article

The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.


Efficacy and safety outcomes in the phase 3 CONTACT-03 study were consistent regardless of prior immunotherapy or tyrosine kinase inhibitor use.

Second-Line Cabozantinib Regimens Exhibit Efficacy in Advanced RCC

Roman Fabbricatore
June 2nd 2025
Article

Efficacy and safety outcomes in the phase 3 CONTACT-03 study were consistent regardless of patients' prior immunotherapy or tyrosine kinase inhibitor use.

Related Content

First-Line Radiotherapy Combo May Show Benefit in Oligoprogressive HCC

First-Line Radiotherapy Combo May Show Benefit in Oligoprogressive HCC

Tim Cortese
June 19th 2025
Article

First-line systemic therapy plus radiation therapy improved PFS vs second-line systemic therapy with or without radiation in hepatocellular carcinoma.


Unveiling Advances in GU Cancers: Insights from Oncology Decoded

Unveiling Advances in GU Cancers: Insights from Oncology Decoded

Manojkumar Bupathi, MD, MS;Benjamin Garmezy, MD;John Burke, MD;Dhaval R. Shah, MBBS
July 3rd 2025
Podcast

Dive into the latest in genitourinary oncology with "Oncology Decoded," featuring discussions on KEYNOTE-564 with RCC.


There appeared to be no extra benefit with the addition of nivolumab to tivozanib among patients included in the phase 3 TiNivo-2 trial.

Tivozanib Shows Efficacy in Pretreated Metastatic RCC

Kyle Doherty
June 11th 2025
Article

There appeared to be no extra benefit with the addition of nivolumab to tivozanib among patients included in the phase 3 TiNivo-2 trial.


A Sneak Peek at 2025 ASCO From the GU Perspective

A Sneak Peek at 2025 ASCO From the GU Perspective

Manojkumar Bupathi, MD, MS;Benjamin Garmezy, MD
May 15th 2025
Podcast

Manojkumar Bupathi, MD, MS, and Benjamin Garmezy, MD, highlight exciting trials in the genitourinary cancer space expected to be presented at 2025 ASCO.


The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.

CAN-2409/EBRT Improves Disease-Free Survival in Localized Prostate Cancer

Roman Fabbricatore
June 3rd 2025
Article

The addition of CAN-2409 to a prodrug and radiation therapy in intermediate-to-high-risk prostate cancer significantly improved cancer-specific outcomes.


Efficacy and safety outcomes in the phase 3 CONTACT-03 study were consistent regardless of prior immunotherapy or tyrosine kinase inhibitor use.

Second-Line Cabozantinib Regimens Exhibit Efficacy in Advanced RCC

Roman Fabbricatore
June 2nd 2025
Article

Efficacy and safety outcomes in the phase 3 CONTACT-03 study were consistent regardless of patients' prior immunotherapy or tyrosine kinase inhibitor use.

Advertisement
About
Advertise
CureToday.com
OncLive.com
OncNursingNews.com
TargetedOnc.com
Editorial
Contact
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Commerce Drive
Cranbury, NJ 08512

609-716-7777

© 2025 MJH Life Sciences

All rights reserved.