Expert Highlights Applications of Proton Therapy in Radiation Oncology

Commentary
Video

The use of proton therapy may offer a more specific depth charge compared with conventional radiation, according to Timothy Chen, MD.

Administering proton therapy to pediatric populations with cancer may serve as a “great application” that helps patients avoid developing mutations and second cancers, says Timothy Chen, MD.

Chen, a board-certified radiation oncologist and medical director of the Central Nervous System Program at Jersey Shore University Medical Center and the director of Proton Therapy in the Department of Radiation Oncology at Hackensack Meridian Health, spoke with CancerNetwork® about the potential applications of proton therapy and benefits this modality may offer compared with standard radiation.

In addition to the potential utility of proton therapy among pediatric populations, Chen highlighted how this technique may demonstrate more precision than others based on what he described as a “depth charge.” For example, it may be possible to administer proton therapy to breast tumors while sparing the lungs from receiving any excess radiation.

Transcript:

Proton therapy is type of radiation but with a different particle hitting the target. If you think about conventional radiation like a pistol, proton [therapy] is like a cannon. It also has a great purpose with what’s called a depth charge. We can set a cannon to be explored at a certain depth. The conventional radiation comes and goes while passing through the structure. With proton therapy, we can say where I want to go and stop right there. With that, there are great applications.

No. 1 is in pediatric [patients with] cancer. Because a child is still growing, the conventional radiation can create mutations, and they could eventually develop a second cancer in their later life. Proton therapy is a particularly great design for pediatric patients [with] cancer; their chance of getting a mutation or a second cancer is smaller.

The second thing is about the depth charge. Because we can set the characteristic of this beam, we can treat quite a large area that’s not accessible with conventional radiation. For example, in breast cancer, the breast sits on top of the chest wall, and as we breathe, the lungs get in [the way and receive] the radiation. But because we can set the depth [with proton therapy], you can confine radiation to the breasts and not touch the lungs.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
T-DXd improved progression-free survival over standard chemotherapy among patients with HR-positive/triple-negative breast cancer in DESTINY-Breast04.
According to Ronan J. Kelly, deciding whether to give nivolumab- or durvalumab-based regimens in gastric cancers may rely on a patient’s frailty.
More follow-up data will better elucidate the impact of frontline use of hypomethylating agents in patients with myelodysplastic syndromes.
Five-year follow-up revealed that patients treated with nivolumab vs placebo in the phase 3 CheckMate 577 trial experienced a “doubling” of survival.
Patients treated with nivolumab in the phase 3 CheckMate 577 trial were less likely to experience progression-related treatment discontinuation vs placebo.
Considering which non–muscle-invasive bladder cancer cases may be cured by surgery alone may help mitigate overtreatment in this patient group.
Event-free survival benefit was observed among BCG-naïve patients with carcinoma in situ undergoing treatment with sasanlimab plus BCG.
Related Content