Ghassan K. Abou-Alfa, MD, Discusses Next Steps in Researching Unresectable HCC

Approval Alert | <b>Tremelimumab Plus Durvalumab for Unresectable Hepatocellular Carcinoma </b>

Future research into the management of unresectable hepatocellular carcinoma may involve combining local therapies with checkpoint inhibitors like durvalumab and tremelimumab, according to Ghassan K. Abou-Alda, MD.

Ghassan K. Abou Alfa, MD, an attending physician at Memorial Sloan Kettering Cancer Center, spoke with CancerNetwork® after the FDA approval of tremelimumab (Imjudo) in combination with durvalumab (Imfinzi) for patients with unresectable hepatocellular carcinoma (HCC) about the next steps in managing the disease. In addition to highlighting the progress that has been made thus far in terms of improving outcomes in patients with HCC, he spotlighted future focuses such as advancing treatment with immune checkpoint inhibitors, as well as combining them with local therapies.


We need to cure [HCC] and we still have ways to go. No question that I humbly and proudly have witnessed this disease start from a median survival of barely 3 months, and worked through different studies at Memorial Sloan Kettering for the last 22 years, and look where we are: We're talking about a mean survival of close to 16.5 months or more. There is no doubt that we are on the right track, but of course, we want more. Why do we need more? We owe our patients that and promise them that. Will there be further advancement of the use of checkpoint inhibitors in a more advanced way? Absolutely. Is it also possible to consider local therapy married with the use of the checkpoint inhibitors? By all means, yes. To that extent, our current study, which is already open in some parts of the world will actually combine chemoembolization for local therapy plus the use of durvalumab and tremelimumab, as we just mentioned.


Imjudo (tremelimumab) in combination with Imfinzi approved in the US for patients with unresectable liver cancer. News Release. AstraZeneca. October 24, 2022. Accessed October 31, 2022.