Jorge Nieva, MD, Discusses the Impact of IMpower010 and New Trials in Progress for Early-Stage NSCLC

CancerNetwork® sat down with Jorge Nieva, MD, at the 2021 ASCO Annual Meeting to talk about the future of clinical trials for early-stage non–small cell lung cancer.

At the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, CancerNetwork® spoke with Jorge Nieva, MD, from Keck School of Medicine of University of Southern California, about how IMpower010 (NCT02486718) made a big impact at this year’s meeting. The trial examined atezolizumab (Tecentriq) and compared it with best supportive care therapy after adjuvant chemotherapy in patients with resected early-stage non–small cell lung cancer. Results from this study indicated that the trial met its primary end point of disease-free survival superiority with atezolizumab (HR, 0.79; 95% CI, 0.64-0.96; 2-sided P = .0205), with overall survival data still immature.


I’m a lung cancer doctor, [and I’m most excited about IMpower010]. I think this will be the biggest splash that comes out [ASCO]. There’s going to be 6 trials in the works asking the same question [of how will adjuvant therapy affect early stage NSCLC]. They’re all going to come out sometime later. I don’t think any of those 6 trials are reporting out at ASCO.


Wakelee H, Altorki N, Zhou C, et al. IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC). J Clin Oncol. 2021;39(suppl 15):8500. doi: 10.1200/JCO.2021.39.15_suppl.8500