M.D. Anderson group unveils new p53 marker

July 23, 2009
Oncology NEWS International, Oncology NEWS International Vol 18 No 7, Volume 18, Issue 7

Houston-based investigators have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

Houston-based investigators have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

Trim24 feeds p53 to the proteasome by attaching targeting ubiquitins to the tumor suppressor. It is highly expressed in tumors and is a target of two known oncogenes in some forms of leukemia (PNAS online, June 30, 2009)