|Articles|June 1, 2007

Oncology NEWS International

  • Oncology NEWS International Vol 16 No 6
  • Volume 16
  • Issue 6

PEG-SN38 Shows Anti-Tumor Activity in Resistant Models

BRIDGEWATER, New Jersey—Enzon Pharmaceuticals, Inc.'s PEG-SN38, a novel polyethyleneglycol-SN38 conjugate, resulted in significant tumor growth inhibition in mice resistant to irinotecan (Camptosar) (a 25% decrease in tumor volume) and outperformed irinotecan when given as a second-round therapy to mice initially sensitive to irinotecan, the company said in a news release. The data were presented at the American Association for Cancer Research 2007 meeting (abstract 1494). Additionally, PEG-SN38 demonstrated long-lasting anti-tumor activity in mouse models of human breast and pancreatic cancers, the company said.

BRIDGEWATER, New Jersey—Enzon Pharmaceuticals, Inc.'s PEG-SN38, a novel polyethyleneglycol-SN38 conjugate, resulted in significant tumor growth inhibition in mice resistant to irinotecan (Camptosar) (a 25% decrease in tumor volume) and outperformed irinotecan when given as a second-round therapy to mice initially sensitive to irinotecan, the company said in a news release. The data were presented at the American Association for Cancer Research 2007 meeting (abstract 1494). Additionally, PEG-SN38 demonstrated long-lasting anti-tumor activity in mouse models of human breast and pancreatic cancers, the company said.

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ACS Launches Major Epidemiology Study

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Pt Selection Key to Radioembolization of Liver Ca's

almost 19 years ago

Million Dollar Gotham Prize Announced

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Diagnostic Dilemma: GI Disease

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Velcade/Doxil Approved for Relapsed or Refractory Multiple Myeloma Pts

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Junovan Fails to Win ODAC Nod for Osteosarcoma Treatment

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Surveillance Colonoscopy Guidelines Not Being Followed

almost 19 years ago

Removing Stage IV Primary May Cut Mortality

almost 19 years ago

Nuclear Export Inhibitors Testing Moving Forward

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ODAC: orBec Yields No 'Substantial Efficacy' in GI GVHD

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