Tanios S. Bekaii-Saab, MD, Discusses Key Findings From a Genomic and Immune Profiling Study in Intrahepatic Cholangiocarcinoma

Video

At ASCO 2021, Tanios S. Bekaii-Saab, MD, talked about some of his research in patients with IDH1/2–positive cholangiocarcinoma presented at the meeting.

At the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, CancerNetwork® spoke with Tanios S. Bekaii-Saab, MD, of Mayo Clinic, about key findings from a genomic and immune profiling study in patients with intrahepatic cholangiocarcinoma. Specifically, he examines the incidence of IDH1/2 mutations and key findings related to these genetic abnormalities.

Transcript:

What we essentially found in our study that [was] presented at ASCO was that close to 20% of patients will have IDH1 or IDH2 [mutations], [which] is very similar to [what] we expected. Two things about IDH1: It seems that IDH1/2 are mutually exclusive, and that is good to see, [as] drivers do not co-occur, at least [in terms of] the drivers that are targetable and can arrest development of the cancer. The other thing is, interestingly, if you have an IDH1 or an IDH2 mutation, you are less likely to find other targetable alterations. You will almost never find an FGFR2 fusion, for example.

Reference

Makawita S, Borad MJ, Carapeto F, et al. IDH1 and IDH2 driven intrahepatic cholangiocarcinoma (IHCC): a comprehensive genomic and immune profiling study. J Clin Oncol. 2021;39(suppl 15):4009. doi:10.1200/JCO.2021.39.15_suppl.4009

Related Videos
Additional analyses of patient-reported outcomes and MRD status in the QuANTUM-First trial are also ongoing, says Harry P. Erba, MD, PhD.
Investigators must continue to explore the space for lisocabtagene maraleucel in mantle cell lymphoma, according to Manali Kamdar, MD.
Those with CML should discuss adverse effects such as nausea or fatigue with their providers to help optimize their quality of life during treatment.
Patients with CML can become an active part of their treatment plan by discussing any questions that come to mind with their providers.
Jorge E. Cortes, MD, emphasizes proper communication between patients with chronic myeloid leukemia and their providers during the treatment course.
Dietary interventions or other medications may help mitigate diarrhea in patients who undergo therapy for chronic myeloid leukemia.
Whether CAR T-cell therapy or T-cell engagers should dominate the multiple myeloma landscape may be hard to determine, says David S. Siegel, MD.
Next steps for research in the multiple myeloma space may include the development of novel CAR T-cell strategies and bispecific antibodies.
Ongoing research may clarify the potential benefit of avelumab when administered in combination with other agents in advanced urothelial carcinoma.
Spatial analyses may help determine factors that influence responses to sacituzumab govitecan-containing regimens in urothelial carcinoma.
Related Content