Allan Y. Chen, MD, PhD | Authors

DNA Topoisomerase I-Targeting Drugs as Radiation Sensitizers

October 01, 1999

Combination chemoradiation, alone or as an adjuvant to surgery, has been shown to improve treatment outcomes in a number of human malignancies, but may be limited by normal tissue toxicities. A primary challenge in

Drug-Radiation Interactions in Tumor Blood Vessels

October 01, 1999

Obliteration of the tumor vasculature is an effective means of achieving tumor regression. Antiangiogenic agents have begun to enter cancer clinical trials. Ionizing radiation activates the inflammatory cascade and increases the