Brian Long, PhD | Authors

Preclinical Studies Using the Intratumoral Aromatase Model for Postmenopausal Breast Cancer

March 02, 1998

To determine the most effective strategies for the treatment of postmenopausal hormone dependent breast cancer, we recently developed a model system in nude mice. In this model, estrogen receptor-positive human breast cancer cells (MCF-7) stably transfected with the aromatase gene are inoculated into ovariectomized, immunosuppressed (nude) mice.