Preclinical Studies Using the Intratumoral Aromatase Model for Postmenopausal Breast Cancer
ByAngela Brodie, PhD,Qing Lu, MD, PhD,Yang Liu, MD,Brian Long, PhD,Ji-ping Wang, MD,Wei Yue, MD, PhD
Published: | Updated:
To determine the most effective strategies for the treatment of postmenopausal hormone dependent breast cancer, we recently developed a model system in nude mice. In this model, estrogen receptor-positive human breast cancer cells (MCF-7) stably transfected with the aromatase gene are inoculated into ovariectomized, immunosuppressed (nude) mice.