Author | Wei Yue, MD, PhD


Preclinical Studies Using the Intratumoral Aromatase Model for Postmenopausal Breast Cancer

March 02, 1998

ByAngela Brodie, PhD|Qing Lu, MD, PhD|Yang Liu, MD|Brian Long, PhD|Ji-ping Wang, MD|Wei Yue, MD, PhD

To determine the most effective strategies for the treatment of postmenopausal hormone dependent breast cancer, we recently developed a model system in nude mice. In this model, estrogen receptor-positive human breast cancer cells (MCF-7) stably transfected with the aromatase gene are inoculated into ovariectomized, immunosuppressed (nude) mice.