Gustavo Dos Santos Fernandes, MD | Authors

Perioperative Treatment of Gastrointestinal Stromal Tumors

January 02, 2009

Gastrointestinal stromal tumors (GISTs) originate from the interstitial cells of Cajal or a precursor and are the most common mesenchymal neoplasms of the gastrointestinal (GI) tract.[1] Although GISTs often present as localized masses, they are typified by a high risk of metastatic relapse, most commonly in the liver and peritoneum.

Trastuzumab: Mechanisms of Resistance and Therapeutic Opportunities

October 01, 2008

The human epidermal growth factor receptor 2 (HER2) is a transmembrane receptor with tyrosine kinase activity overexpressed in about 20% to 25% of invasive carcinomas of the breast.