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Gustavo Dos Santos Fernandes, MD

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Articles

Perioperative Treatment of Gastrointestinal Stromal Tumors

Gustavo Dos Santos Fernandes, MD;Charles D. Blanke, MD, FACP;Daniela Freitas, MD;Rodrigo Guedes, MD;Paulo M. Hoff, MD, FACP

January 2nd 2009

Gastrointestinal stromal tumors (GISTs) originate from the interstitial cells of Cajal or a precursor and are the most common mesenchymal neoplasms of the gastrointestinal (GI) tract.[1] Although GISTs often present as localized masses, they are typified by a high risk of metastatic relapse, most commonly in the liver and peritoneum.

Trastuzumab: Mechanisms of Resistance and Therapeutic Opportunities

Aknar Calabrich, MD;Gustavo Dos Santos Fernandes, MD;Artur Katz, MD

October 1st 2008

The human epidermal growth factor receptor 2 (HER2) is a transmembrane receptor with tyrosine kinase activity overexpressed in about 20% to 25% of invasive carcinomas of the breast.