Jonathan L. Kaufman, MD | Authors




Insights Into the Appropriate Use of New Antimyeloma Therapies

January 15, 2017

Unfortunately, while survival outcomes with novel therapies have improved, the fraction of patients with multiple myeloma who are cured of their disease remains low. Immune therapies offer the hope for further improvement in outcomes and higher rates of cure.

Non-Secretory Myeloma: A Clinician’s Guide

September 15, 2013

Numerous small series of patients suggest that the prognosis for non-secretory myeloma patients is likely no worse than the prognosis for patients with traditional secretory myeloma, and in some settings may be superior.

Melphalan or No Melphalan: That Is the Question

October 15, 2010

Clinical outcomes data for all of oncology include those from trial after trial demonstrating poor outcomes in older patients with cancer. Whether these are the result of limited biologic reserve, poor performance status, or inherently worse biological disease at the time of diagnosis, such age-based disparities have continued unabated for decades. However, for the first time, older patients with multiple myeloma (MM) are starting to enjoy the kinds of remission durations and overall survival (OS) seen in younger patients. In this review by Dr. Harousseau, we see that through the use of regimens such as MPV (melphalan and prednisone plus bortezomib), MPT (melphalan and prednisone plus thalidomide), MPR (melphalan and prednisone plus lenalidomide), VMPT (bortezomib, melphalan, prednisone, and thalidomide), and Rd (lenalidomide and low-dose dexamethasone), we can begin to provide older patients with MM with a median OS approaching the 4- to 5-year mark-a far cry from the median OS of 2.5 to 3 years seen with MP just 15 years ago. So what are the remaining hurdles and challenges to be addressed in the upcoming 10 years?

Treatment of Multiple Myeloma: Whence Truth Over Belief?

April 30, 2009

New treatments and an improved biologic understanding of why malignant plasma cells are able to survive have dramatically changed the natural history of multiple myeloma. Along with these new treatments, therapeutic options for patients at each stage of their disease have become a collection of confusing consonants. Combinations such as Rd,[1] CRd,[2] VD,[3] VTD,[4] VRD,[5] CyBorD,[6] PAD,[7] and BiRD[8] all produce impressive response rates in the induction therapy setting, and can be used for patients with relapsed disease as well.

Commentary (Kaufman/Lonial): New Treatments for Multiple Myeloma

December 01, 2005

Treatment options for patientswith myeloma have movedfrom the relatively ineffectivecombinations of cytotoxic agents andcorticosteroids, to the widespread useof high-dose therapy and autologousbone marrow or peripheral blood stemcell transplant. Through this transition,the overall survival for patientshas nearly doubled from a previousmedian survival of 2 to 2.5 years, upto 4 to 5 years based on the transplantarms of several large randomizedclinical trials.[1-3] In this issue ofONCOLOGY, Dr. Richardson andcolleagues extensively detail the recentadvances in myeloma therapythat involve the use of more “modern”or novel agents such as thalidomide(Thalomid), lenalidomide (Revlimid),and bortezomib (Velcade). Theseagents are of monumental importance in the assault on myeloma as theyhave provided much needed advancesfor patients with relapsed and refractorymyeloma and, in doing so,have set the stage for the next majorrevolution in myeloma therapy.