Mohamed E. Salem, MD

Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets—PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor

July 15, 2017

Here we review drugs that target the EGFR and VEGF pathways, focusing on patient selection, drug toxicities, and how to choose agents for first-line therapy.

Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets—PART 2: Approaches Beyond First-Line Therapy, and Novel Biologic Agents Under Investigation

July 15, 2017

Here we review the evidence for use of biologic agents in the second-line setting and beyond. We also discuss off-label indications for biologics in selected patient populations, as well as biologics currently under development.

The Growing Challenge of Young Adults With Colorectal Cancer

May 16, 2017

In this review, we address specific issues pertaining to AYA patients with colorectal cancer, including evaluation for hereditary colorectal cancer syndromes, clinicopathologic and biologic features unique to AYA patients with colorectal cancer, treatment outcomes, and survivorship.

Molecular Differences Between Left-Sided Colon and Rectal Cancers

January 26, 2017

Mohamed E. Salem, MD

This video examines a pair of studies that looked at molecular variances and clinical differences between left-sided colon and rectal cancers.

Neoadjuvant Combined-Modality Therapy for Locally Advanced Rectal Cancer and Its Future Direction

June 15, 2016

Here we discuss the evolution of standard therapy for rectal cancer patients and the use of preoperative CRT for the treatment of locally advanced disease. Treatment schemes that have attempted to broaden the horizons of standard therapy include the use of induction chemotherapy and “watch-and-wait” approaches.