Oncology Vol 28 No 4_Suppl_1

April 15, 2014

Radiobiology studies suggest that soft tissue sarcoma (STS) is a radioresistant tumor. We reviewed our institutional outcomes of patients treated with stereotactic body radiation therapy for metastatic STS.

April 15, 2014

To investigate the efficacy and morbidity of limb-sparing surgery with intraoperative radiotherapy (IORT) for patients with primary, nonmetastatic extremity and limb-girdle soft tissue sarcoma (STS) at high risk for recurrence.

April 15, 2014

Among patients with the top 10 causes of cancer death, those with Medicaid or without insurance were more likely to present with advanced-stage disease. This group also experienced worse survival when controlling for demographic information, stage at diagnosis, and receipt of definitive treatment.

April 15, 2014

Cancer treatment studies are well represented in high-impact oncology as well as general medical journals. We sought to evaluate the distribution and characteristics of oncology studies by intervention (radiation, surgery, cytotoxic chemotherapy, or targeted/systemic agents) in six high-impact oncology and general medical journals.

April 15, 2014

To evaluate recurrence patterns and overall survival in patients treated with adjuvant radiation after surgical staging for stage II endometrial carcinoma. Secondary goals include identification of prognostic factors for recurrence.

April 15, 2014

We have been treating patients with positive pelvic nodes with extended-field intensity-modulated radiation therapy (IMRT) to address the PA region prophylactically with a concomitant boost to the involved nodes. The purpose of this study is to assess regional control rates and recurrence patterns with this technique.

April 15, 2014

Linear accelerator-based stereotactic radiosurgery (SRS) is an effective treatment for selected melanoma patients with brain metastases. Recently, BRAF inhibitors have shown efficacy in stage IV melanoma. We sought to determine the effectiveness of SRS in patients with melanoma who are also being treated with BRAF inhibitors.

April 15, 2014

Cancer survivors may experience myriad late effects, and the Institute of Medicine recommends that survivorship care plans be provided to all. This study explores the willingness of health care providers (HCPs) and survivors to utilize mobile devices (MDs) for this purpose.

April 15, 2014

Here, we present the 1- and 2-year survival outcomes from patients with stage IB2–IVB cervical cancer treated with triapine radiochemotherapy.

April 15, 2014

We describe a method for prospectively collecting real-time, longitudinal datasets evaluating central nervous system (CNS)-directed IGRT across a multinational pediatrics consortium.

April 15, 2014

Our experience leads us to suspect that hypofractionation, as used in the US, increases toxicity without improving efficacy.

April 15, 2014

In this study, we present our institutional data on the clinical outcomes of radiation therapy plus temozolomide for anaplastic gliomas.

April 15, 2014

The purpose of our study is to report our institutional outcomes in treatment of brainstem metastases with gamma knife stereotactic radiosurgery for comparison.

April 15, 2014

Temporal lobe radionecrosis is a potential complication of high-dose radiation therapy for skull base tumors. The risk of radionecrosis increases with absolute doses greater than 60 Gy, but little data are available regarding potential partial volume effects when higher-dose conventionally fractionated radiotherapy is employed.

April 15, 2014

Previous data from our institution suggest that imaging evidence of extracapsular extension, identified on pretreatment CT scans, independently predicts for worse distant control and survival for oropharyngeal squamous cell cancer (OPC) patients undergoing radiation therapy. In this present study, we sought to validate these findings in non-OPC head and neck squamous cell cancers.

April 15, 2014

Our objective was to analyze the incidence of second primary cancer limited to the head and neck in a population with primary squamous cell carcinoma of the head and neck and its temporal trends in the human papillomavirus (HPV) era.

April 15, 2014

The purpose of this study is to report the long-term progression-free survival (PFS), overall survival (OS), and late-toxicity outcomes in pediatric patients with craniopharyngioma who have been treated with IMRT.

April 15, 2014

Low-grade gliomas (LGGs) are slow-growing, primary brain tumors that frequently recur after primary surgical treatment. Recent work has established the activation of the PI3K/mTOR pathway in most LGGs, raising the possibility that mTOR inhibitors, such as everolimus (RAD001), may benefit patients with LGG. Early imaging markers of treatment response and disease progression are needed to assess patients undergoing investigational therapy.

April 15, 2014

The purpose of our study is to evaluate the outcomes of patients treated with SBRT in the postoperative setting.

April 15, 2014

Single-fraction palliative radiotherapy for bone metastasis appears to be much more available for cancer patients receiving end-of-life care within the United Veterans Healthcare Administration when compared with the general US health care system.

April 15, 2014

The goal of this study is to compare survival, local control, and toxicity outcomes for non–small-cell lung cancer patients treated with SBRT for centrally versus peripherally located tumors.

April 15, 2014

Neoadjuvant chemoradiation is a standard treatment of locally advanced esophageal cancer. Preventive strategies to minimize postoperative morbidity will be important to help improve the clinical outcomes of patients. We investigated the factors associated with an increased incidence of anastomotic leaks among patients treated with neoadjuvant chemoradiation.

April 15, 2014

In this retrospective study, we sought to investigate the dose prescription pattern use in the US for patients receiving SBRT.

April 15, 2014

We evaluated the correlation between patient survival and reduction in gross tumor volume (GTV) using weekly cone-beam computed tomography (CBCT) to assess whether this could be prognostic of survival. We hypothesized that a greater percent decline in primary lung tumor volume during the course of treatment would correlate to improved patient survival.

April 15, 2014

The goal of this study was to optimize combination therapy with PARP1 inhibition and radiation for clinical assessment by establishing the most effective drug/radiation treatment schedule, determining the degree of PARP1-mediated radiosensitization across a range of drug doses, and identifying early biomarkers predictive of long-term treatment efficacy in preclinical BCa models.

April 15, 2014

There is conflicting evidence regarding the benefit of postmastectomy radiation therapy (PMRT) for pathologic stage T3N0M0 breast cancers. We performed a Surveillance, Epidemiology, and End Results (SEER) analysis to investigate the benefit of PMRT in these patients.

April 15, 2014

Purpose: Rhabdomyosarcoma of the perineal and perianal region (PRMS) has poor outcomes. We analyzed prognostic factors and patterns of failure, with an emphasis on radiotherapy for locoregional control.

April 15, 2014

To compare rates of pathologic response, downstaging, local control, and treatment-related toxicity in patients treated in a prospective phase II trial of preoperative short-course radiotherapy and sequential FOLFOX (folinic acid, fluorouracil, oxaliplatin) chemotherapy with patients treated at our institution with preoperative long-course chemoradiotherapy and adjuvant chemotherapy.

April 15, 2014

Although adverse sequelae of chemoradiation (CRT) for head and neck cancer (HNC) have been extensively detailed in recent years, the effects of CRT on voice and speech quality remain poorly characterized. We investigated changes in patient-reported voice and speech quality (VSQ) after CRT in two prospective studies of organ-sparing CRT for locally advanced oropharyngeal cancer (OPC).

April 15, 2014

To characterize the utilization of postprostatectomy radiation for patients with prostate cancer (CaP) at a National Cancer Institute (NCI)-designated Comprehensive Cancer Center over the past decade, given the introduction of robotic prostatectomy and the publication of multiple phase III trials showing a benefit for adjuvant postprostatectomy radiation.

April 15, 2014

Permanent prostate brachytherapy (PPB) is a well-established treatment for localized prostate cancer. The future of PPB relies upon the quality training of future residents; however, current training requirements are frequently inadequate. Our objective was to design and implement a unique training program that utilized a phantom-based simulator to teach the process of quality assurance (QA) and improve PPB education.

April 15, 2014

This prospective study expands upon prior studies to further evaluate SBRT efficacy and QOL for a large patient population that includes low-, intermediate-, and high-risk prostate cancer patients.

April 15, 2014

To investigate outcomes in intermediate-risk prostate cancer patients receiving dose-escalated external beam radiation therapy (RT) with or without short-course androgen deprivation therapy (ADT).

April 15, 2014

To determine if there is an influence of sociodemographic factors on biochemical control (bNED) and overall survival (OS) in prostate cancer (CaP).

April 15, 2014

This study estimates RT doses received by organs of interest during protocol treatment to determine whether the findings might explain these observations.

April 15, 2014

We hypothesized that the promising outcomes with partial-bladder treatment might be due to the effects of hypofractionation. We thus aimed to analyze the clinical impact of hypofractionation on local control and to characterize the radiation response of a bladder cancer cell line with regard to clonogenic survival.

April 15, 2014

One clinical observation is that a decrease in tumor enhancement on CT scans after cytotoxic therapy is generally regarded as a good response. We hypothesized that measuring this phenomenon would correlate with local control of human pancreatic adenocarcinoma (PDAC).

April 15, 2014

Chemoradiation for biliary tract cancers (BTCs) has been associated with substantial toxicities due to the large, irregular target volumes surrounded by critical normal tissues. The purpose of this study was to evaluate patient tolerability and acute toxicity of chemoradiation with intensity-modulated radiation therapy (IMRT) for BTCs.

April 15, 2014

In this study, we investigate the role of ALDH expression in predicting survival and patterns of disease recurrence in pancreatic adenocarcinoma patients treated with chemoradiation following pancreatectomy.

April 15, 2014

For patients with pancreatic cancer, we compared direct care costs, patient retention rates, and survival outcomes for patients treated in our institution’s pancreatic multidisciplinary clinics (MDCs) with those evaluated within the institution but outside the MDC.

April 15, 2014

Evaluation of liver function following high-dose liver stereotactic body radiation therapy (SBRT) in the treatment of metastatic and primary malignancies of the liver utilizing the Child-Pugh score classification system.

April 15, 2014

Hypofractionated whole-breast irradiation (HF-WBI) following breast-conserving surgery has produced excellent outcomes, but utilization remains limited. We evaluated the impact of a clinical pathway on adoption of HF-WBI in a large integrated radiation oncology network.

April 15, 2014

An unmet clinical need in breast cancer (BC) management is the identification of which patients will respond to radiation therapy (RT). We hypothesized that the integration of post-RT clonogenic survival data with gene expression data across a large spectrum of BC cell lines would generate a BC-specific RT sensitivity signature predictive for RT response in BC patients and allow identification of patients with tumors refractive to conventional therapy.

April 15, 2014

Using repeated measures analyses, we analyzed the data from the originally published N06C4 prospective trial and present here the CTCAE-based temporal profile of acute skin toxicities, when time factor was considered.

April 15, 2014

We aim to examine the difference between outcomes in young women (aged < 40 y) treated with breast-conserving therapy consisting of partial breast surgery and radiation therapy vs mastectomy.

April 15, 2014

The goal of this study is to use a national database to examine how practice patterns changed prior to versus after publication of the ASTRO accelerated partial breast irradiation guideline.

April 15, 2014

The goal of this study is to assess locoregional outcomes associated with breast cancer subtype in stage III locally advanced breast cancer patients after surgery, radiation therapy, and modern systemic therapy.

April 15, 2014

We examined whether presenting stage at time of breast cancer diagnosis has changed over time in Florida and whether there is variation in this change with respect to race, ethnicity, and socioeconomic status.