77 A Radio Opaque Suture May Improve Radiation Target Delineation in Post Lumpectomy Patients With Breast Cancer: A Retrospective Analysis

Publication
Article
Miami Breast Cancer Conference® Abstracts Supplement42nd Annual Miami Breast Cancer Conference® - Abstracts
Volume 39
Issue 4
Pages: 57

77 A Radio Opaque Suture May Improve Radiation Target Delineation in Post Lumpectomy Patients With Breast Cancer: A Retrospective Analysis

77 A Radio Opaque Suture May Improve Radiation Target Delineation in Post Lumpectomy Patients With Breast Cancer: A Retrospective Analysis

Background/Significance

The identification of the tumor bed following lumpectomy is vital for successful radiation treatment, both for a breast radiation boost and more fundamentally in the partial breast setting. However, identification of the tumor cavity on a planning CT scan can be complicated as postsurgical seromas will inversely decrease with time and preoperative imaging may not anatomically correlate. In addition, the radiation target should correlate with the tumor pathology size. VeraForm is a radio-opaque continuous multiplane marker that is sutured into the operative bed during the lumpectomy. The aim of this study is to compare VeraForm markers (VF), surgical clip (SC) placement, and no clips (NC) on target delineation in relation to the tumor bed.

Materials and Methods

Beginning in July 2023, a single breast surgeon placed VF in lumpectomy. We retrospectively reviewed 48 women, 19 women with VF and compared with 13 women with SC and 24 women with NC. The tumor volume was calculated by taking the surgical specimen 3-dimensional measurements and multiplying it by π/6. We created a ratio between the specimen and the CTV (radiation target volume of the tumor bed, which was created by a board certified radiation oncologist). We then used a 2 sample Welch t-test to compare 3 populations.

Results

The population was mainly T0 (28%) and T1 (58%). The treatment was whole breast with a cavity boost in 57% and partial breast in 43%. The medium weight of the patients between VF, SC, and NC was similar (169 lbs, 174 lbs, 169 lbs, respectively), and the time from surgery to radiation mapping was similar (33 days, 40 days, 42 days, respectively). The tumor volume for VF, SC, and NC was 40 mL, 47 mL, and 54 mL, respectively (P = not specified). However, the VF ratio to tumor volume had less variance than NC (P = .0436) but showed no improvement over the SC (P = .289). SC did not show an improvement over NC (P = .239).

Conclusion

In this single-institution retrospective study, VF led to a target volume that was more consistent with the tumor specimen size than no markers. However, it did not yield an improvement over SC placement.

Articles in this issue

65 The Outcomes of Nipple Sparing Goldilocks Mastectomy in a Primarily Overweight and Obese Population
65 The Outcomes of Nipple Sparing Goldilocks Mastectomy in a Primarily Overweight and Obese Population
67 Confocal Laser Scanning Microscopy (CLSM) for Intraoperative Histopathological Margin Assessment in Breast Conservation Surgery
67 Confocal Laser Scanning Microscopy (CLSM) for Intraoperative Histopathological Margin Assessment in Breast Conservation Surgery
68 Upper Extremity Disability Assessment Following Breast Cancer Surgery Using QuickDASH in an Ethnic Minority Population
68 Upper Extremity Disability Assessment Following Breast Cancer Surgery Using QuickDASH in an Ethnic Minority Population
70 Malignancy Upgrade Rates of Discordant Breast Lesions
70 Malignancy Upgrade Rates of Discordant Breast Lesions
71 Beyond the Surface: Suspicious Nipple Lesions
71 Beyond the Surface: Suspicious Nipple Lesions
72 Breast Cancer After Breast Augmentation: A Multicenter Collaborative Study Of Patient Management and Outcomes
72 Breast Cancer After Breast Augmentation: A Multicenter Collaborative Study Of Patient Management and Outcomes
73 Short- and Long-Term Outcomes in Use of Titanium-Coated Polypropylene Meshes in Immediate Breast Reconstruction: A Cost-Effective and Safe Option?
73 Short- and Long-Term Outcomes in Use of Titanium-Coated Polypropylene Meshes in Immediate Breast Reconstruction: A Cost-Effective and Safe Option?
74 Lessons Learned From a Breast Surgery ERAS Program in an Oncologic Ambulatory Center
74 Lessons Learned From a Breast Surgery ERAS Program in an Oncologic Ambulatory Center
75 Comparing 21-Gene Assay Recurrence Scores Before and After Preoperative Radiation Boost in Patients Enrolled in a Phase 2 Prospective Clinical Trial
75 Comparing 21-Gene Assay Recurrence Scores Before and After Preoperative Radiation Boost in Patients Enrolled in a Phase 2 Prospective Clinical Trial
76 Electromagnetic Chip Bracketed vs Wire Bracketed Localization in Breast Conserving Surgery
76 Electromagnetic Chip Bracketed vs Wire Bracketed Localization in Breast Conserving Surgery
77 A Radio Opaque Suture May Improve Radiation Target Delineation in Post Lumpectomy Patients With Breast Cancer: A Retrospective Analysis
77 A Radio Opaque Suture May Improve Radiation Target Delineation in Post Lumpectomy Patients With Breast Cancer: A Retrospective Analysis
78 Comparison of Positive Margin Rate of Breast Cancer in Higher BMI Patients
78 Comparison of Positive Margin Rate of Breast Cancer in Higher BMI Patients
79 Case Series of Pathologic Upgrade After Reconstructive Breast Surgery
79 Case Series of Pathologic Upgrade After Reconstructive Breast Surgery
81 Assessing Recurrence Likelihood in Hormone Receptor–Positive/HER2-Negative Breast Cancer Patients Directly From MRI Using Imaging AI
81 Assessing Recurrence Likelihood in Hormone Receptor–Positive/HER2-Negative Breast Cancer Patients Directly From MRI Using Imaging AI
82 Efficacy, Safety, and Biomarker Analysis of ICARUS-BREAST01: A Phase 2 Study of Patritumab Deruxtecan (HER3-DXd) in Patients With HR+/HER2– Advanced Breast Cancer
82 Efficacy, Safety, and Biomarker Analysis of ICARUS-BREAST01: A Phase 2 Study of Patritumab Deruxtecan (HER3-DXd) in Patients With HR+/HER2– Advanced Breast Cancer

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