Bone marrow aspiration enhances detection of leukemia cells

November 17, 2009
Oncology NEWS International, Oncology NEWS International Vol 18 No 11, Volume 18, Issue 11

Scientists in New Mexico are experimenting with a nanotechnology device that quantifies the amount of nanoparticle-bound tumor cells in a tissue sample and offers increased sensitivity to minimal residual disease (Cancer Res 69:6839-6847, 2009).

Scientists in New Mexico are experimenting with a nanotechnology device that quantifies the amount of nanoparticle-bound tumor cells in a tissue sample and offers increased sensitivity to minimal residual disease (Cancer Res 69:6839-6847, 2009).

The marrow biopsy needle targets tumor cells with nanoparticles and then preferentially extracts the cells with a magnetic needle. The group used anti-CD34 antibody loaded magnetic nanoparticles to detect CD34-positive cells as an indicator of leukemia. To quantify the cells recovered, they coupled this nanoparticle-mediated fishing for leukemic cells with the Superconducting Quantum Interference Device (SQUID).

The work is a collaborative effort between Senior Scientific and the University of New Mexico Health Science Center, both in Albuquerque.