Genetic Variations Linked to Post-Transplant Outcomes in Leukemia Patients

March 23, 2017

This video examines research that found that certain genetic variations of both leukemia patients undergoing bone marrow transplant and their unrelated donors were associated with poor outcomes.  

In this video, Theresa Hahn, PhD, of the Roswell Park Cancer Institute, discusses research that looked at genetic variations in the DNA of both leukemia patients undergoing bone marrow transplant (BMT) and their unrelated donors.

Analyzing survival data from over 150 transplant centers in the United States, Hahn and colleagues found that variants in two regions of the genomes of leukemia patients receiving BMT were associated with disease relapse. In the genomes of donors, variants in two regions were linked with an increased risk of death for recipients within the first year after transplant.

The results of the study were presented last month at the annual BMT Tandem Meeting in Orlando, Florida.

Video courtesy of Roswell Park Cancer Institute.